Abstract

? ? After surgery, a short-term change in mental status (delirium) is frequent complication that is under- recognized and can affect patient's long-term ability to live at home. This study uses state-of-the-art brain imaging to compare long-term brain changes in patients with and without delirium after surgery. If the hypotheses are confirmed, this will alter our fundamental understanding of delirium as a short-term disorder and future studies can use imaging to prevent, identify, and treat delirium. ? ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Research Grants (R03)
Project #
1R03AG029861-01A1
Application #
7387042
Study Section
Aging Systems and Geriatrics Study Section (ASG)
Program Officer
Wagster, Molly V
Project Start
2007-09-30
Project End
2009-08-31
Budget Start
2007-09-30
Budget End
2008-08-31
Support Year
1
Fiscal Year
2007
Total Cost
$56,700
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Chester, Jennifer G; Grande, Laura J; Milberg, William P et al. (2011) Cognitive screening in community-dwelling elders: performance on the clock-in-the-box. Am J Med 124:662-9
Chester, Jennifer Gonik; Rudolph, James L (2011) Vital signs in older patients: age-related changes. J Am Med Dir Assoc 12:337-43
Azar, Armin R; Chopra, Mohit P; Cho, Lydia Y et al. (2011) Remission in major depression: results from a geriatric primary care population. Int J Geriatr Psychiatry 26:48-55
Grande, Laura J; Rudolph, James L; Milberg, William P et al. (2011) Detecting cognitive impairment in individuals at risk for cardiovascular disease: the ""Clock-in-the-Box"" screening test. Int J Geriatr Psychiatry 26:969-75
Harrington, Mary Beth; Kraft, Malissa; Grande, Laura J et al. (2011) Independent association between preoperative cognitive status and discharge location after cardiac surgery. Am J Crit Care 20:129-37
Jones, Richard N; Rudolph, James L; Inouye, Sharon K et al. (2010) Development of a unidimensional composite measure of neuropsychological functioning in older cardiac surgery patients with good measurement precision. J Clin Exp Neuropsychol 32:1041-9
Rudolph, J L; Schreiber, K A; Culley, D J et al. (2010) Measurement of post-operative cognitive dysfunction after cardiac surgery: a systematic review. Acta Anaesthesiol Scand 54:663-77
Rudolph, James L; Zanin, Nicole M; Jones, Richard N et al. (2010) Hospitalization in community-dwelling persons with Alzheimer's disease: frequency and causes. J Am Geriatr Soc 58:1542-8
Rudolph, James L; Inouye, Sharon K; Jones, Richard N et al. (2010) Delirium: an independent predictor of functional decline after cardiac surgery. J Am Geriatr Soc 58:643-9
Leritz, Elizabeth C; Salat, David H; Milberg, William P et al. (2010) Variation in blood pressure is associated with white matter microstructure but not cognition in African Americans. Neuropsychology 24:199-208

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