? ? After surgery, a short-term change in mental status (delirium) is frequent complication that is under- recognized and can affect patient's long-term ability to live at home. This study uses state-of-the-art brain imaging to compare long-term brain changes in patients with and without delirium after surgery. If the hypotheses are confirmed, this will alter our fundamental understanding of delirium as a short-term disorder and future studies can use imaging to prevent, identify, and treat delirium. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Research Grants (R03)
Project #
5R03AG029861-02
Application #
7502155
Study Section
Aging Systems and Geriatrics Study Section (ASG)
Program Officer
Wagster, Molly V
Project Start
2007-09-30
Project End
2010-08-31
Budget Start
2008-09-01
Budget End
2010-08-31
Support Year
2
Fiscal Year
2008
Total Cost
$55,566
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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Rudolph, James L; Inouye, Sharon K; Jones, Richard N et al. (2010) Delirium: an independent predictor of functional decline after cardiac surgery. J Am Geriatr Soc 58:643-9
Leritz, Elizabeth C; Salat, David H; Milberg, William P et al. (2010) Variation in blood pressure is associated with white matter microstructure but not cognition in African Americans. Neuropsychology 24:199-208

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