Acne is an important human skin disorder and is thought to be caused by skin commensal P. acnes. We have identified two types of hyaluronidases, made by P. acnes, that are either pro or anti- inflammatory. Human colonization by P. acnes that encodes the pro-inflammatory hyaluronidase appears to be associated with development of moderate acne, and conversely colonization with P. acnes that encodes the anti-inflammatory hyaluronidase is associated with healthy skin. Based on our findings, we propose that hyaluronidases play a role in acne by affecting the pro-inflammatory potential of P. acnes strains.
For Aim 1, we propose to study the pathogenic mechanisms of both hyaluronidases in murine models of acne.
For Aim 2, we further seek to investigate the association between hyaluronidase type and acne-genic potential using one of the best characterized collection of P. acnes strains, from individuals with or without acne.

Public Health Relevance

We have identified two types of P. acnes hyaluronidases, one that is immune stimulatory and the other that is immunomodulatory. We propose to investigate the potential role of both hyaluronidases in acne disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21AI138053-01
Application #
9516693
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Huntley, Clayton C
Project Start
2018-06-01
Project End
2020-05-31
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048