The capacity to represent the world in terms of numerically distinct objects is a milestone in early cognitive development and forms the foundation for more complex thought and behavior. Failure to develop this capacity places infants at significant risk for later developmental difficulties. Recent research has revealed important developmental changes in infants' ability to use featural information to individuate objects. However, relatively little is known about the neural mechanisms that underlie these changes, in large part because there are a limited number of non-invasive techniques available to measure brain function in infants. Hence, there is a critical need to identify new methods to specify the relation between behavior and brain function in object processing. One (1) such method is near-infrared spectroscopy (NIRS), an optical imaging technique that uses changes in cerebral blood volume as an indicator of neural activation. Because NIRS is safe and non-invasive, can be used during behavioral tasks, and provides spatial and temporal information about neural activation, it is ideal for infant research of this kind. The research proposed in this application will use NIRS to identify changes in neural activation during an object processing task. The objective of this application is to identify the neural basis of infants' ability to use 2 kinds of featural information, shape and color, to individuate objects. The central hypothesis is that infants' capacity to individuate objects using shape and color differences will be associated with unique, well-defined patterns of neural activation. This hypothesis has been formulated on the basis of behavioral and neuroimaging data collected in our lab. The rationale for the proposed research is that once we have identified the neural substrates that support featurally-based object individuation in the infant, it will be possible to formulate a developmental model of object processing that focuses on brain-behavior relations. This information can be used to help guide the development of diagnostic and intervention techniques that can be used with infants at risk for object processing difficulties, and will provide the impetus for new research that examines the extent to which normal patterns of behavior and brain function can be altered by differences in early experience.
| Wilcox, Teresa; Stubbs, Jessica; Hirshkowitz, Amy et al. (2012) Functional activation of the infant cortex during object processing. Neuroimage 62:1833-40 |
| Woods, Rebecca J; Wilcox, Teresa; Armstrong, Jennifer et al. (2010) Infants' representations of three-dimensional occluded objects. Infant Behav Dev 33:663-71 |
| Wilcox, Teresa; Haslup, Jennifer A; Boas, David A (2010) Dissociation of processing of featural and spatiotemporal information in the infant cortex. Neuroimage 53:1256-63 |
| Wilcox, Teresa; Bortfeld, Heather; Woods, Rebecca et al. (2009) Hemodynamic changes in the infant cortex during the processing of featural and spatiotemporal information. Neuropsychologia 47:657-62 |
| Wilcox, Teresa; Bortfeld, Heather; Woods, Rebecca et al. (2008) Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration. Dev Sci 11:361-70 |
