We and others have observed that oxidants are formed during inflammatory tissue injury and are known to be generated through stimulation of leukocytes. In order to evaluate the role of oxidants in the pathogenicity of inflammatory disease, it will be essential to define the cellular and molecular targets of oxidants. The applicant proposes to study the effect of specific oxidants on molecular targets of cells. In particular, the proposed studies are aimed at: 1.0 Definition of cellular targets of H202 1.1 Definition of cellular targets of HOCl and chloramines 1.2 Determination of the effects of oxidants derived from stimulated PMNs on target cells with special emphasis on damage of DNA. Once specific targets of oxidants are defined on a molecular level, it will be possible to determine oxidant involvement in inflammatory disease by looking for the formation of these """"""""footprints"""""""" in vivo.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI027506-04
Application #
3455036
Study Section
Pathology A Study Section (PTHA)
Project Start
1989-07-01
Project End
1994-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037