Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29AI036259-03
Application #
2072435
Study Section
Experimental Immunology Study Section (EI)
Project Start
1994-08-15
Project End
1999-07-31
Budget Start
1996-08-15
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
La Jolla Institute
Department
Type
DUNS #
603880287
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Schuler, K; Lu, C; Chang, H D et al. (2001) Circumvention of MHC class II restriction by genetic immunization. Vaccine 20:630-4
Gerloni, M; Xiong, S; Mukerjee, S et al. (2000) Functional cooperation between T helper cell determinants. Proc Natl Acad Sci U S A 97:13269-74
Rogers, P R; Croft, M (2000) CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen. J Immunol 164:2955-63
Gramaglia, I; Cooper, D; Miner, K T et al. (2000) Co-stimulation of antigen-specific CD4 T cells by 4-1BB ligand. Eur J Immunol 30:392-402
Gerloni, M; Miner, K T; Xiong, S et al. (1999) Activation of CD4 T cells by somatic transgenesis induces generalized immunity of uncommitted T cells and immunologic memory. J Immunol 162:3782-9
Gramaglia, I; Mauri, D N; Miner, K T et al. (1999) Lymphotoxin alphabeta is expressed on recently activated naive and Th1-like CD4 cells but is down-regulated by IL-4 during Th2 differentiation. J Immunol 162:1333-8
Rogers, P R; Croft, M (1999) Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance. J Immunol 163:1205-13
Gramaglia, I; Weinberg, A D; Lemon, M et al. (1998) Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J Immunol 161:6510-7
Rogers, P R; Grey, H M; Croft, M (1998) Modulation of naive CD4 T cell activation with altered peptide ligands: the nature of the peptide and presentation in the context of costimulation are critical for a sustained response. J Immunol 160:3698-704
Joseph, S B; Miner, K T; Croft, M (1998) Augmentation of naive, Th1 and Th2 effector CD4 responses by IL-6, IL-1 and TNF. Eur J Immunol 28:277-89

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