Pericellular Matrix and Osteoarthritis

Lee, Greta M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29AR043883-02
• Application #: 2083642
• Study Section: Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
• Project Start: 1995-09-25
• Project End: 2000-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: University of North Carolina Chapel Hill
• Department: Anatomy/Cell Biology
• Type: Schools of Medicine
• DUNS #: 078861598
• City: Chapel Hill
• State: NC
• Country: United States
• Zip Code: 27599

Publications

Zhang, Z; Fan, J; Becker, K G et al. (2006) Comparison of gene expression profile between human chondrons and chondrocytes: a cDNA microarray study. Osteoarthritis Cartilage 14:449-59

Graff, Ronald D; Lee, Greta M (2003) Microplate live cell assay system for early events in mechanotransduction. Anal Biochem 318:181-6

Summey Jr, Brett T; Graff, Ronald D; Lai, Thung-Sheng et al. (2002) Tissue transglutaminase localization and activity regulation in the extracellular matrix of articular cartilage. J Orthop Res 20:76-82

Larson, Christopher M; Kelley, Scott S; Blackwood, A Denene et al. (2002) Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production. Matrix Biol 21:349-59

Lee, Greta M; Tioran, Marianne E; Jansen, Marilyn et al. (2002) Development of selective tolerance to interleukin-1beta by human chondrocytes in vitro. J Cell Physiol 192:113-24

Lee, G M; Paul, T A; Slabaugh, M et al. (2000) The incidence of enlarged chondrons in normal and osteoarthritic human cartilage and their relative matrix density. Osteoarthritis Cartilage 8:44-52

Graff, R D; Lazarowski, E R; Banes, A J et al. (2000) ATP release by mechanically loaded porcine chondrons in pellet culture. Arthritis Rheum 43:1571-9

Trickey, W R; Lee, G M; Guilak, F (2000) Viscoelastic properties of chondrocytes from normal and osteoarthritic human cartilage. J Orthop Res 18:891-8

Lee, G M; Loeser, R F (1999) Cell surface receptors transmit sufficient force to bend collagen fibrils. Exp Cell Res 248:294-305

Guilak, F; Jones, W R; Ting-Beall, H P et al. (1999) The deformation behavior and mechanical properties of chondrocytes in articular cartilage. Osteoarthritis Cartilage 7:59-70