Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
3R29CA063023-04S1
Application #
2433739
Study Section
Special Emphasis Panel (ZRG7-SSS-1 (07))
Project Start
1994-01-15
Project End
1998-12-31
Budget Start
1997-01-01
Budget End
1997-12-31
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Georgetown University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Lee, S A; Dritschilo, A; Jung, M (2001) Role of ATM in oxidative stress-mediated c-Jun phosphorylation in response to ionizing radiation and CdCl2. J Biol Chem 276:11783-90
Varghese, S; Schmidt-Ullrich, R K; Dritschilo, A et al. (1999) Enhanced radiation late effects and cellular radiation sensitivity in an ATM heterozygous breast cancer patient. Radiat Oncol Investig 7:231-7
Varghese, S; Jung, M (1998) Overexpression of Rb and E2F-1 in ataxia-telangiectasia lymphocytes. Arch Pharm Res 21:640-4
Lee, S A; Dritschilo, A; Jung, M (1998) Impaired ionizing radiation-induced activation of a nuclear signal essential for phosphorylation of c-Jun by dually phosphorylated c-Jun amino-terminal kinases in ataxia telangiectasia fibroblasts. J Biol Chem 273:32889-94
Lee, S J; Dimtchev, A; Lavin, M F et al. (1998) A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kappaB. Oncogene 17:1821-6
Jung, M; Zhang, Y; Dimtchev, A et al. (1998) Impaired regulation of nuclear factor-kappaB results in apoptosis induced by gamma radiation. Radiat Res 149:596-601
Jung, M; Zhang, Y; Dritschilo, A (1997) Expression of a dominant negative I kappa B-alpha modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis. Radiat Oncol Investig 5:265-8
Jung, M; Lee, S A; Zhang, Y et al. (1997) Regulation of p53 in response to ionizing radiation in ataxia telangiectasia fibroblasts. Int J Radiat Oncol Biol Phys 37:417-22
Jung, M; Kondratyev, A; Lee, S A et al. (1997) ATM gene product phosphorylates I kappa B-alpha. Cancer Res 57:24-7
Jung, M; Zhang, Y; Lee, S et al. (1995) Correction of radiation sensitivity in ataxia telangiectasia cells by a truncated I kappa B-alpha. Science 268:1619-21

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