Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29DK042486-05
Application #
3464125
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1990-06-01
Project End
1995-05-31
Budget Start
1993-12-01
Budget End
1994-05-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Ramkumar, V; Ravi, R; Wilson, M C et al. (1994) Identification of A1 adenosine receptors in rat cochlea coupled to inhibition of adenylyl cyclase. Am J Physiol 267:C731-7
Mulheron, J G; Casanas, S J; Arthur, J M et al. (1994) Human 5-HT1A receptor expressed in insect cells activates endogenous G(o)-like G protein(s). J Biol Chem 269:12954-62
Gettys, T W; Fields, T A; Raymond, J R (1994) Selective activation of inhibitory G-protein alpha-subunits by partial agonists of the human 5-HT1A receptor. Biochemistry 33:4283-90
Palmer, T M; Gettys, T W; Jacobson, K A et al. (1994) Desensitization of the canine A2a adenosine receptor: delineation of multiple processes. Mol Pharmacol 45:1082-94
McGill, J M; Basavappa, S; Gettys, T W et al. (1994) Secretin activates Cl- channels in bile duct epithelial cells through a cAMP-dependent mechanism. Am J Physiol 266:G731-6
Raymond, J R; Arthur, J M; Casanas, S J et al. (1994) Alpha 2A adrenergic receptors inhibit cAMP accumulation in embryonic stem cells which lack Gi alpha 2. J Biol Chem 269:13073-5
Collins, S; Daniel, K W; Rohlfs, E M et al. (1994) Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Mol Endocrinol 8:518-27
Gettys, T W; Sheriff-Carter, K; Moomaw, J et al. (1994) Characterization and use of crude alpha-subunit preparations for quantitative immunoblotting of G proteins. Anal Biochem 220:82-91
Davies, M G; Ramkumar, V; Gettys, T W et al. (1994) The expression and function of G-proteins in experimental intimal hyperplasia. J Clin Invest 94:1680-9
Kineman, R D; Gettys, T W; Frawley, L S (1994) Paradoxical effects of dopamine (DA): Gi alpha 3 mediates DA inhibition of PRL release while masking its PRL-releasing activity. Endocrinology 135:790-3

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