Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM046513-05
Application #
2184016
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1992-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Notre Dame
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
824910376
City
Notre Dame
State
IN
Country
United States
Zip Code
46556
Rupert, P B; Mollah, A K; Mossing, M C et al. (2000) The structural basis for enhanced stability and reduced DNA binding seen in engineered second-generation Cro monomers and dimers. J Mol Biol 296:1079-90
Mossing, M C (1998) Solution structure and dynamics of a designed monomeric variant of the lambda Cro repressor. Protein Sci 7:983-93
Jana, R; Hazbun, T R; Fields, J D et al. (1998) Single-chain lambda Cro repressors confirm high intrinsic dimer-DNA affinity. Biochemistry 37:6446-55
Jana, R; Hazbun, T R; Mollah, A K et al. (1997) A folded monomeric intermediate in the formation of lambda Cro dimer-DNA complexes. J Mol Biol 273:402-16
Albright, R A; Mossing, M C; Matthews, B W (1996) High-resolution structure of an engineered Cro monomer shows changes in conformation relative to the native dimer. Biochemistry 35:735-42
Mollah, A K; Aleman, M A; Albright, R A et al. (1996) Core packing defects in an engineered Cro monomer corrected by combinatorial mutagenesis. Biochemistry 35:743-8