The GABAergic system may play a significant role in the pathogenesis as well as in the pharmacological control of epilepsy and other brain diseases. Concentrations and rates of synthesis of GABA may reflect the activity of the GABAergic system. The goal of the proposed research is to develop quantitative single volume and multivolume 1H NMR methods for measuring brain gamma amino butyric acid (GABA) concentration and rates of synthesis in human brain. The methods will be applied in studies of human subjects to determine the precision of the measurement, the accuracy of the resonance assignment, and to measure the relaxation properties needed for GABA absolute quantitation. An animal model will be used to validate the NMR method by comparison with conventional chemical assay. The development of 1H NMR methods for measuring GABA will provide an important new tool for studying the human GABAergic system.
| Goddard, Andrew W; Mason, Graeme F; Appel, Michael et al. (2004) Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. Am J Psychiatry 161:2186-93 |
| Hyder, Fahmeed; Kida, Ikuhiro; Behar, Kevin L et al. (2003) Dominant events that modulate mass transfer coefficient of oxygen in cerebral cortex. Adv Exp Med Biol 530:401-11 |
| Shulman, Robert G; Hyder, Fahmeed; Rothman, Douglas L (2003) Cerebral metabolism and consciousness. C R Biol 326:253-73 |
| Rothman, Douglas L; Behar, Kevin L; Hyder, Fahmeed et al. (2003) In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annu Rev Physiol 65:401-27 |
| Xu, Fuqiang; Liu, Nian; Kida, Ikuhiro et al. (2003) Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb. Proc Natl Acad Sci U S A 100:11029-34 |
| Shulman, Robert G; Hyder, Fahmeed; Rothman, Douglas L (2002) Biophysical basis of brain activity: implications for neuroimaging. Q Rev Biophys 35:287-325 |
| Smith, Arien J; Blumenfeld, Hal; Behar, Kevin L et al. (2002) Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI. Proc Natl Acad Sci U S A 99:10765-70 |
| Hyder, Fahmeed; Rothman, Douglas L; Shulman, Robert G (2002) Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI. Proc Natl Acad Sci U S A 99:10771-6 |
| Sibson, N R; Mason, G F; Shen, J et al. (2001) In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during. J Neurochem 76:975-89 |
| de Graaf, R A; Pan, J W; Telang, F et al. (2001) Differentiation of glucose transport in human brain gray and white matter. J Cereb Blood Flow Metab 21:483-92 |
Showing the most recent 10 out of 55 publications
