The research projects currently under way in this laboratory comprise a broad program designed to probe the role of class II MHC molecules in immunity and self-tolerance; in the failure of self-tolerance, and to develop means to potentiate or to block the action of MHC molecules in mediating the immune response to foreign antigens, self antigens and self-tumor antigens. The knowledge of structure-function relationships of MHC class II molecules gained in these experiments will then be applied to several animal disease models and human disease states. Parallel experiments are designed to determine the immuno-regulatory role of lymphokines, which directly or indirectly regulate the level of expression and site of expression of class II MHC molecules. A separate set of experiments will expand our on-going study of MHC class II allelic polymorphism by searching for class II polymorphic sequences in species which have diverged from the human evolutionary line five million years ago (chimpanzees) and approximately 20 million years ago (cynomolgus monkeys). These experiments should permit an evaluation of the evolutionary conservation of class II MHC polymorphic sequences critical for the function of these molecules in regulating the immune response.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA049734-06
Application #
2093412
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1989-09-08
Project End
1996-08-31
Budget Start
1994-09-30
Budget End
1995-08-31
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Stanford University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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Fugger, L; Michie, S A; Rulifson, I et al. (1994) Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response. Proc Natl Acad Sci U S A 91:6151-5
Yang, X D; Michie, S A; Tisch, R et al. (1994) Cell adhesion molecules: a selective therapeutic target for alleviation of IDDM. J Autoimmun 7:859-64

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