Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA015378-23
Application #
2086338
Study Section
Special Emphasis Panel (NSS)
Project Start
1990-12-29
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Chiu, S; Oleinick, N L (1998) Radioprotection of cellular chromatin by the polyamines spermine and putrescine: preferential action against formation of DNA-protein crosslinks. Radiat Res 149:543-9
Chiu, S; Oleinick, N L (1997) Radioprotection against the formation of DNA double-strand breaks in cellular DNA but not native cellular chromatin by the polyamine spermine. Radiat Res 148:188-92
Balasubramaniam, U; Oleinick, N L (1995) Preferential cross-linking of matrix-attachment region (MAR) containing DNA fragments to the isolated nuclear matrix by ionizing radiation. Biochemistry 34:12790-802
Chiu, S M; Xue, L Y; Friedman, L R et al. (1995) Differential dependence on chromatin structure for copper and iron ion induction of DNA double-strand breaks. Biochemistry 34:2653-61
Xue, L Y; Friedman, L R; Oleinick, N L et al. (1994) Induction of DNA damage in gamma-irradiated nuclei stripped of nuclear protein classes: differential modulation of double-strand break and DNA-protein crosslink formation. Int J Radiat Biol 66:11-21
Oleinick, N L; Balasubramaniam, U; Xue, L et al. (1994) Nuclear structure and the microdistribution of radiation damage in DNA. Int J Radiat Biol 66:523-9
Murthi, K K; Friedman, L R; Oleinick, N L et al. (1993) Formation of DNA-protein cross-links in mammalian cells by levuglandin E2. Biochemistry 32:4090-7
Agarwal, M L; Larkin, H E; Zaidi, S I et al. (1993) Phospholipase activation triggers apoptosis in photosensitized mouse lymphoma cells. Cancer Res 53:5897-902
Chiu, S M; Xue, L Y; Friedman, L R et al. (1993) Copper ion-mediated sensitization of nuclear matrix attachment sites to ionizing radiation. Biochemistry 32:6214-9
Chiu, S M; Xue, L Y; Friedman, L R et al. (1992) Chromatin compaction and the efficiency of formation of DNA-protein crosslinks in gamma-irradiated mammalian cells. Radiat Res 129:184-91

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