Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA023296-13
Application #
3481958
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1978-04-01
Project End
1990-09-30
Budget Start
1990-04-01
Budget End
1990-09-30
Support Year
13
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Traganos, F; Darzynkiewicz, Z (1994) Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations. Methods Cell Biol 41:185-94
Darzynkiewicz, Z; Gorczyca, W; Lassota, P et al. (1993) Altered sensitivity of DNA in situ to denaturation in apoptotic cells. Ann N Y Acad Sci 677:334-40
Gorczyca, W; Melamed, M R; Darzynkiewicz, Z (1993) Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay. Toxicol Lett 67:249-58
Kapuscinski, J; Kimmel, M (1993) Thermodynamical model of mixed aggregation of intercalators with caffeine in aqueous solution. Biophys Chem 46:153-63
Black, R S; Bouvier, M M; Sheu, K F et al. (1992) Presence of typical neuronal markers in serially cultured cells from adult human brain. J Neurol Sci 111:104-12
Bruno, S; Del Bino, G; Lassota, P et al. (1992) Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Leukemia 6:1113-20
Traganos, F; Ardelt, B; Halko, N et al. (1992) Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells. Cancer Res 52:6200-8
Mikulski, S M; Viera, A; Darzynkiewicz, Z et al. (1992) Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines. Br J Cancer 66:304-10
Hotz, M A; Traganos, F; Darzynkiewicz, Z (1992) Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturation. Exp Cell Res 201:184-91
Bruno, S; Ardelt, B; Skierski, J S et al. (1992) Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes. Cancer Res 52:470-3

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