Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA024844-18
Application #
2087304
Study Section
Special Emphasis Panel (NSS)
Project Start
1979-09-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Lawrence Berkeley National Laboratory
Department
Anatomy/Cell Biology
Type
Organized Research Units
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720
Garbe, James C; Vrba, Lukas; Sputova, Klara et al. (2014) Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. Cell Cycle 13:3423-35
Nijjar, Tarlochan; Bassett, Ekaterina; Garbe, James et al. (2005) Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells. Oncogene 24:3369-76
Stampfer, Martha R; Garbe, James; Nijjar, Tarlochan et al. (2003) Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines. Oncogene 22:5238-51
Stampfer, Martha R; Yaswen, Paul (2003) Human epithelial cell immortalization as a step in carcinogenesis. Cancer Lett 194:199-208
Stampfer, M R; Garbe, J; Levine, G et al. (2001) Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc Natl Acad Sci U S A 98:4498-503
Nonet, G H; Stampfer, M R; Chin, K et al. (2001) The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells. Cancer Res 61:1250-4
Yaswen, P; Stampfer, M R (2001) Epigenetic changes accompanying human mammary epithelial cell immortalization. J Mammary Gland Biol Neoplasia 6:223-34
Stampfer, M R; Yaswen, P (2000) Culture models of human mammary epithelial cell transformation. J Mammary Gland Biol Neoplasia 5:365-78
Kim, D W; Sovak, M A; Zanieski, G et al. (2000) Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells. Carcinogenesis 21:871-9
Ferguson, A T; Evron, E; Umbricht, C B et al. (2000) High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. Proc Natl Acad Sci U S A 97:6049-54

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