Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
7R37CA030388-12
Application #
3482186
Study Section
Special Emphasis Panel (NSS)
Project Start
1981-07-01
Project End
1993-12-31
Budget Start
1991-11-01
Budget End
1991-12-31
Support Year
12
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Dhar-Mascareno, Manya; Mascareno, Eduardo; Golde, David W (2009) Early signaling by vascular endothelial growth factor and placental growth factor in human bone marrow-derived endothelial cells is mediated by superoxide. J Vasc Res 46:601-8
Heaney, Mark L; Gardner, Jeffrey R; Karasavvas, Nicos et al. (2008) Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Res 68:8031-8
Perez-Cruz, Isabel; Carcamo, Juan M; Golde, David W (2007) Caspase-8 dependent TRAIL-induced apoptosis in cancer cell lines is inhibited by vitamin C and catalase. Apoptosis 12:225-34
K C, Sagun; Carcamo, Juan M; Golde, David W (2006) Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC. Mutat Res 593:64-79
Chen, Jian; Carcamo, Juan M; Golde, David W (2006) The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling. J Biol Chem 281:22421-6
Dhar-Mascareno, Manya; Pedraza, Alicia; Golde, David W (2005) PI3-kinase activation by GM-CSF in endothelium is upstream of Jak/Stat pathway: role of alphaGMR. Biochem Biophys Res Commun 337:551-6
KC, Sagan; Carcamo, Juan M; Golde, David W (2005) Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury. FASEB J 19:1657-67
Dhar-Mascareno, Manya; Carcamo, Juan M; Golde, David W (2005) Hypoxia-reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C. Free Radic Biol Med 38:1311-22
DeYulia Jr, Garrett J; Carcamo, Juan M; Borquez-Ojeda, Oriana et al. (2005) Hydrogen peroxide generated extracellularly by receptor-ligand interaction facilitates cell signaling. Proc Natl Acad Sci U S A 102:5044-9
Araten, David J; Golde, David W; Zhang, Rong H et al. (2005) A quantitative measurement of the human somatic mutation rate. Cancer Res 65:8111-7

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