Prenatal Cocaine - Acute and Delayed Functional Toxicity

Sparber, Sheldon B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Drug Abuse (NIDA)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37DA004979-05
• Application #: 2117358
• Study Section: Drug Abuse Biomedical Research Review Committee (DABR)
• Project Start: 1988-08-01
• Project End: 2000-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: University of Minnesota Twin Cities
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 168559177
• City: Minneapolis
• State: MN
• Country: United States
• Zip Code: 55455

Publications

Mendoza-Baumgart, Mary Irene; Pravetoni, Marco; Sparber, Sheldon B (2007) Inhibition of nitric oxide synthase enhances cocaine's developmental toxicity: vascular and CNS effects. Neuropsychopharmacology 32:940-5

Schrott, Lisa M; Sparber, Sheldon B (2004) Suppressed fever and hypersensitivity responses in chicks prenatally exposed to opiates. Brain Behav Immun 18:515-25

Mendoza-Baumgart, Mary Irene; Pravetoni, Marco; Sparber, Sheldon B (2004) Vasoconstriction caused by cocaine is enhanced by sodium salicylate: is inducible nitric oxide synthase mRNA related? Neuropsychopharmacology 29:1294-300

Schrott, Lisa M; Baumgart, Mary Irene; Zhang, Xuewei et al. (2002) Prenatal opiate withdrawal activates the chick embryo hypothalamic pituitary-adrenal axis and dilates vitelline blood vessels via serotonin(2) receptors. J Pharmacol Exp Ther 303:257-64

Venturini, L; Sparber, S B (2001) Salicylate and cocaine: interactive toxicity during chicken mid-embryogenesis. Free Radic Biol Med 30:198-207

Larson, E B; Schrott, L M; Bordone, L et al. (2001) Embryonic cocaine exposure and corticosterone: serotonin(2) receptor mediation. Pharmacol Biochem Behav 69:71-5

Schrott, L M; Sparber, S B (2001) Embryonic ""binge"" cocaine exposure alters neural-immune and neural-endocrine interactions in young chickens: involvement of serotonin(2) receptors. Brain Res Dev Brain Res 130:99-107

Castelli, M C; Venturini, L; Sparber, S B (2001) Cocaine and salicylate: documentation of hydroxyl radical formation in hearts and brains of 18-day-old chick embryos and unexpected interactive toxicity. Psychopharmacology (Berl) 156:23-31

Bollweg, G L; Sparber, S B (1999) Voltage associated with spontaneous embryonic motility in the developing chicken: an automated characterization during mid-late embryogenesis. Dev Psychobiol 34:5-19

Schrott, L M; Sweeney, W A; Bodensteiner, K E et al. (1999) Late embryonic ritanserin exposure fails to alter normal responses to immune system stimulation in young chicks. Pharmacol Biochem Behav 64:81-8