Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HD020521-18
Application #
6636810
Study Section
Special Emphasis Panel (NSS)
Program Officer
Oster-Granite, Mary Lou
Project Start
1996-04-29
Project End
2006-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
18
Fiscal Year
2003
Total Cost
$285,307
Indirect Cost
Name
Emory University
Department
Genetics
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Alpatov, Roman; Lesch, Bluma J; Nakamoto-Kinoshita, Mika et al. (2014) A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell 157:869-81
Zhu, Gengzhen; Li, Yujing; Zhu, Fei et al. (2014) Coordination of engineered factors with TET1/2 promotes early-stage epigenetic modification during somatic cell reprogramming. Stem Cell Reports 2:253-61
Nelson, David L; Orr, Harry T; Warren, Stephen T (2013) The unstable repeats--three evolving faces of neurological disease. Neuron 77:825-43
Wang, Tao; Bray, Steven M; Warren, Stephen T (2012) New perspectives on the biology of fragile X syndrome. Curr Opin Genet Dev 22:256-63
Santoro, Michael R; Bray, Steven M; Warren, Stephen T (2012) Molecular mechanisms of fragile X syndrome: a twenty-year perspective. Annu Rev Pathol 7:219-45
Henderson, Christina; Wijetunge, Lasani; Kinoshita, Mika Nakamoto et al. (2012) Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen. Sci Transl Med 4:152ra128
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Gross, Christina; Nakamoto, Mika; Yao, Xiaodi et al. (2010) Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neurosci 30:10624-38
Collins, Stephen C; Bray, Steven M; Suhl, Joshua A et al. (2010) Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males. Am J Med Genet A 152A:2512-20
Collins, Stephen C; Coffee, Brad; Benke, Paul J et al. (2010) Array-based FMR1 sequencing and deletion analysis in patients with a fragile X syndrome-like phenotype. PLoS One 5:e9476

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