Bisphenol A (BPA) is one of the highest production chemicals in the world. It is used in polycarbonate beverage containers, food packaging, linings of food cans, and sealants for teeth. Public health concerns have been raised about BPA because recent studies demonstrate: 1) that it is an endocrine disruptor that acts as an estrogen at low doses;2) that it leaches from consumer products into food and water;3) and that human exposure is nearly ubiquitous. Animal studies suggest that BPA alters sexual and reproductive development, including sexually-dimorphic alterations in brain structure and behavior;increased weight gain;and earlier puberty. Because of these health concerns, several countries and U.S. states are considering legislation to ban BPA. However, almost no studies to date have examined the health effects of BPA in humans. This proposal seeks to address this data gap by examining the health effects of developmental BPA exposure in a cohort of children living in California. The CHAMACOS Study is a longitudinal birth cohort study that has followed ~500 low-income children living in a predominantly Mexican-American, farmworker community from before birth to age 9. Children's growth, health, neurodevelopment, and behavior have been assessed at birth and age 6 months, 1, 2, 3 1/2, 5, and 7 years of age and urine and/or blood samples were collected at each time point. In this rich dataset, the intent is to examine the association of BPA exposure in utero and in childhood with child growth and development.
The specific aims are: 1) to measure BPA concentrations in urine collected from ~400 mothers during pregnancy and from their children at 6 months, 5 years, and 9 years of age. All samples, except those at age 9, have already been collected: 2) to determine whether maternal BPA concentrations are associated with maternal (TSH, T3, T4) and child (TSH) thyroid hormone levels. 3) to determine whether maternal and childhood BPA concentrations are associated with cognitive functioning and behavior at age 5 years.;4) To determine whether maternal and childhood BPA exposure is associated with body mass at age 5 or age 9 years;and 5) To determine whether maternal and childhood BPA exposure is associated with metabolic syndrome at age 9 years. Data has already been collected on thyroid levels in mother and child and neurobehavioral development and body mass at age 5 years. Metabolic syndrome diagnosis will be determined from new data gathered at age 9 (blood pressure, waist circumference, lipids and glucose in fasting blood). This project is uniquely suited for this Grand Opportunities RFA because it uses an extant dataset and banked samples, it focuses on developmental exposures, and it can be begun immediately and completed in 2 years. This is a potentially high-impact project that can provide immediate answers about the human health effects of BPA exposure to legislators and policy makers and lays the groundwork for future investigations.

Public Health Relevance

The proposed research will provide some of the first data on the human health effects of BPA exposure and address key data gaps identified by advisory and regulatory bodies. By relying mainly on existing data and banked samples, we will accelerate the science by completing the research in just two years. In addition, measurement of BPA in this cohort will lay the foundation for future examination of multiple other outcomes, such as asthma (including spirometry), immune function (Th1 and Th2 cytokines), and pubertal onset, in this rich and unique dataset.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
High Impact Research and Research Infrastructure Programs (RC2)
Project #
5RC2ES018792-02
Application #
7942902
Study Section
Special Emphasis Panel (ZES1-LWJ-J (O1))
Program Officer
Gray, Kimberly A
Project Start
2009-09-30
Project End
2012-12-31
Budget Start
2010-08-01
Budget End
2012-12-31
Support Year
2
Fiscal Year
2010
Total Cost
$713,880
Indirect Cost
Name
University of California Berkeley
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Berger, Kimberly; Eskenazi, Brenda; Balmes, John et al. (2018) Associations between prenatal maternal urinary concentrations of personal care product chemical biomarkers and childhood respiratory and allergic outcomes in the CHAMACOS study. Environ Int 121:538-549
Volberg, Vitaly; Harley, Kim; Calafat, Antonia M et al. (2013) Maternal bisphenol a exposure during pregnancy and its association with adipokines in Mexican-American children. Environ Mol Mutagen 54:621-8
Harley, Kim G; Gunier, Robert B; Kogut, Katherine et al. (2013) Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children. Environ Res 126:43-50
Harley, Kim G; Aguilar Schall, Raul; Chevrier, Jonathan et al. (2013) Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort. Environ Health Perspect 121:514-20
Quirós-Alcalá, Lesliam; Eskenazi, Brenda; Bradman, Asa et al. (2013) Determinants of urinary bisphenol A concentrations in Mexican/Mexican--American pregnant women. Environ Int 59:152-60
Chevrier, Jonathan; Gunier, Robert B; Bradman, Asa et al. (2013) Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. Environ Health Perspect 121:138-44
Volberg, Vitaly; Harley, Kim G; Aguilar, Raul S et al. (2013) Associations between perinatal factors and adiponectin and leptin in 9-year-old Mexican-American children. Pediatr Obes 8:454-63