Abstract

The proposed investigations are designed to expand and provide a better understanding of the chronopharmacology and chronotherapeutics of specific compounds on the physiological system. Attempts will be made to develop a pharmacological agent which will phase shift behavioral patterns by altering the circadian levels of certain biogenic amines at specific times of the day. The research also proposes to investigate the role of circadian rhythms in aged animals relative to pain sensitivity, brain amines and neuroactive peptide levels. Studies are also designed to examine and determine the time for best therapeutics regimens for new antiinflammatory steroids currently being synthesized in our lab. Another study will investigate the nocturnal differences in asthma pathophysiology and the circadian effects on the optimum time for kinetics and therapy of the bronchodilator theophylline in healthy volunteers and asthmatic patients. It is hoped that results obtained from the proposed studies will contribute to a better understanding of the chronopharmacology and chronotherapeutics of various drugs and thus promote more effective and safer treatment regimens.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Minority Biomedical Research Support Thematic Project Grants (S11)
Project #
1S11RR002660-01
Application #
3522320
Study Section
General Research Support Program Advisory Committee (GRS)
Project Start
1985-09-30
Project End
1989-09-29
Budget Start
1985-09-30
Budget End
1986-09-29
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Florida Agricultural and Mechanical University
Department
Type
Schools of Pharmacy
DUNS #
City
Tallahassee
State
FL
Country
United States
Zip Code
32307

  Publications

Khan, M Omar F; Lee, Henry J (2008) Synthesis and pharmacology of anti-inflammatory steroidal antedrugs. Chem Rev 108:5131-45
Omar, M; Khan, F; Park, Kwan K et al. (2007) New steroidal anti-inflammatory antedrugs: 21-thioalkylether derivatives of methyl 16-prednisolone carboxylates. Med Chem 3:572-5
Park, Kwan-Kyun; Ko, Dong-Hoon; You, Zhengqing et al. (2006) Synthesis and pharmacological evaluations of new steroidal anti-inflammatory antedrugs: 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-3,20-dioxo-pregna-1,4-diene-16alpha-carboxylate (FP16CM) and its derivatives. Steroids 71:83-9
You, Zhengqing; Lee, Henry Young (2006) New AZT conjugates as potent anti-HIV agents. Nucleosides Nucleotides Nucleic Acids 25:37-54
Park, Kwan-K; Ko, Dong-H; You, Z et al. (2006) In vitro anti-inflammatory activities of new steroidal antedrugs: [16alpha,17alpha-d] Isoxazoline and [16alpha,17alpha-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of prednisolone and 9alpha-fluoroprednisolone. Steroids 71:183-8
Khan, M Omar F; Park, Kwan K; Lee, Henry J (2005) Antedrugs: an approach to safer drugs. Curr Med Chem 12:2227-39
Park, Kwan-kyun; Ko, Dong-hoon; You, Zhengqing et al. (2004) Chirality effect of C-20 on metabolism of methyl 11beta,17alpha,20-trihydroxy-3-oxo-1,4-pregnadien-21-oate derivatives. Steroids 69:87-91
You, Zhengqing; Mian, A Moshin; Agarwal, Ram P et al. (2003) Synthesis, anti-HIV, and cytotoxic activity of new AZT conjugates of steroid acids. Nucleosides Nucleotides Nucleic Acids 22:2049-60
Park, Kwan-Kyun; Ko, Dong-Hoon; You, Zhengqing et al. (2003) Metabolism of steroidal anti-inflammatory antedrugs in vitro: methyl 3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-16alpha-carboxylate; its 9alpha-fluorinated, and their 21-O-acyl derivatives. Steroids 68:315-9
Ko, Dong-Hoon; Heiman, Ann S; Hudson, Charles E et al. (2002) New steroidal antiinflammatory antedrugs: Methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and its 21-O-acyl derivatives. Steroids 67:211-9

Showing the most recent 10 out of 26 publications