The Immunology and Inflammation training program at NYU School of Medicine (NYUSoM) provides pre- doctoral and post-doctoral training at the interface between immunology and human disease. The Program trains students and postdoctoral fellows in basic immunology as well as its applications in host- pathogen interactions, autoimmune and inflammatory diseases, and antitumor immunity. A long-term goal of the program is to train a new cadre of researchers in the broad and interdisciplinary area of immunology and its relation to inflammatory processes. The first cycle of the program supported multiple successful trainees, all of whom currently continue training or employment in academic immunology research. The training program currently has 30 faculty who are highly productive scientists with extensive mentoring experience. The faculty mentors all share a common interest in understanding basic immunological mechanisms and how the dysregulation of these mechanisms by genetic and environmental factors leads to disease. In addition, NYUSoM is undertaking a major expansion of its immunology research base at all levels and through multiple departments and centers. To match this existing research strength and ongoing expansion in the field of immunology, we propose a training program with 4 pre-doctoral and 2 post-doctoral positions. The program complements and interacts with other existing training programs at NYUSoM, but provides a unique curriculum and training experience with rigorous courses and seminars in an environment that encourages diversity. Trainees will acquire the ability to critically evaluate scientific data and literature and will develop their writing and presentation skills through participation in the immunology seminar series, work-in-progress presentations, journal clubs and an annual retreat. The successful trainees will represent a new generation of scientists who can contribute to the development of novel therapies to treat inflammatory diseases.

Public Health Relevance

Inflammation is a basic immunological mechanism that helps to protect the host from injury and infection under normal physiological conditions. Chronic inflammation is a pervasive component in many human diseases including chronic infections, autoimmune diseases, vascular and neurological diseases and cancer. Training a new generation of the brightest scientists in the study of immunology and inflammation will facilitate the understanding and ultimately treatment of multiple diseases of public health importance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI100853-08
Application #
9688902
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Gondre-Lewis, Timothy A
Project Start
2012-07-01
Project End
2022-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
8
Fiscal Year
2019
Total Cost
Indirect Cost
Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Yang, Lu; Fanok, Melania H; Mediero-Munoz, Aranzazu et al. (2018) Augmented Th17 Differentiation Leads to Cutaneous and Synovio-Entheseal Inflammation in a Novel Model of Psoriatic Arthritis. Arthritis Rheumatol 70:855-867
Lau, Colleen M; Tiniakou, Ioanna; Perez, Oriana A et al. (2018) Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells. J Exp Med 215:2265-2278
Kreslavsky, Taras; Wong, Jason B; Fischer, Maria et al. (2018) Control of B-1a cell development by instructive BCR signaling. Curr Opin Immunol 51:24-31
Kirkling, Margaret E; Cytlak, Urszula; Lau, Colleen M et al. (2018) Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells. Cell Rep 23:3658-3672.e6
Martin, Patricia K; Marchiando, Amanda; Xu, Ruliang et al. (2018) Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota. Nat Microbiol 3:1131-1141
Rahman, Karishma; Fisher, Edward A (2018) Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression. Front Cardiovasc Med 5:32
Fanok, Melania H; Sun, Amy; Fogli, Laura K et al. (2018) Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma. J Invest Dermatol 138:1116-1125
Xu, Mo; Pokrovskii, Maria; Ding, Yi et al. (2018) c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature 554:373-377
Cullis, Jane; Das, Shipra; Bar-Sagi, Dafna (2018) Kras and Tumor Immunity: Friend or Foe? Cold Spring Harb Perspect Med 8:
Upadhaya, Samik; Sawai, Catherine M; Papalexi, Efthymia et al. (2018) Kinetics of adult hematopoietic stem cell differentiation in vivo. J Exp Med 215:2815-2832

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