This proposal is for the fourth competitive renewal of the training grant, Predoctoral Training of Neuroscientists, 5T32 GM008471, at the University of Minnesota. Trainees in this program are pursuing a Ph.D. through the Graduate Program in Neuroscience that spans 9 colleges and 29 departments throughout the University. The mission of this predoctoral training program is to train outstanding neuroscientists who will be prepared for successful careers in academic research and teaching, industry and government/public service. The challenge ahead is to train neuroscientists who possess the diverse knowledge and research skills required by this highly multidisciplinary and dynamic field. The program provides students with broad fundamentals of neuroscience and in-depth research experience. The training program funds predoctoral students primarily during their second year in the Graduate Program in Neuroscience. The program is built around a core of didactic coursework in neuroscience, dissertation research, and exposure to neuroscience on the national level. Flexibility and time for in-depth development of collateral fields of knowledge and research skills are provided. Several unique educational opportunities are available, including a unique 4 week neuroscience laboratory course and hands on workshops in state-of-the-art techniques. Time and attention are given to the students' professional development. A group of 56 trainers is proposed that reflects the diversity of the areas of study and research techniques in neuroscience. Research interests range from the cellular and molecular to the systems and behavior levels. Each trainer directs a productive research program and has demonstrated commitment to teaching and training. The trainers are united by their participation in the Graduate Program in Neuroscience. An impressive array of scientific and institutional resources is available to the trainees, including substantial direct support for this training grant.

Public Health Relevance

The graduates of this program will have been trained with a strong, broad foundation in neuroscience as well as the interdisciplinary skills needed for the neuroscience workforce of tomorrow. Trained to be independent researchers, the graduates will serve the health care needs of the nation in academics, teaching, industry, government and public service.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008471-25
Application #
9304225
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Nie, Zhongzhen
Project Start
1993-07-01
Project End
2018-07-31
Budget Start
2017-07-01
Budget End
2018-07-31
Support Year
25
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Neurosciences
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Sweis, Brian M; Larson, Erin B; Redish, A David et al. (2018) Altering gain of the infralimbic-to-accumbens shell circuit alters economically dissociable decision-making algorithms. Proc Natl Acad Sci U S A 115:E6347-E6355
Montgomery, Jacob E; Wahlstrom-Helgren, Sarah; Wiggin, Timothy D et al. (2018) Intraspinal serotonergic signaling suppresses locomotor activity in larval zebrafish. Dev Neurobiol :
Satrom, Katherine M; Ennis, Kathleen; Sweis, Brian M et al. (2018) Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats. J Neuroinflammation 15:82
Nippert, Amy R; Biesecker, Kyle R; Newman, Eric A (2018) Mechanisms Mediating Functional Hyperemia in the Brain. Neuroscientist 24:73-83
Teravskis, Peter J; Covelo, Ana; Miller, Eric C et al. (2018) A53T Mutant Alpha-Synuclein Induces Tau-Dependent Postsynaptic Impairment Independently of Neurodegenerative Changes. J Neurosci 38:9754-9767
Sweis, Brian M; Redish, A David; Thomas, Mark J (2018) Prolonged abstinence from cocaine or morphine disrupts separable valuations during decision conflict. Nat Commun 9:2521
Zeidler, Zachary; Brandt-Fontaine, Mikaela; Leintz, Caara et al. (2018) Targeting the Mouse Ventral Hippocampus in the Intrahippocampal Kainic Acid Model of Temporal Lobe Epilepsy. eNeuro 5:
Christenson Wick, Zoé; Krook-Magnuson, Esther (2018) Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research. Front Cell Neurosci 12:151
Pérez Ortiz, Judit M; Mollema, Nissa; Toker, Nicholas et al. (2018) Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model. Neurobiol Dis 116:93-105
Sweis, Brian M; Thomas, Mark J; Redish, A David (2018) Beyond simple tests of value: measuring addiction as a heterogeneous disease of computation-specific valuation processes. Learn Mem 25:501-512

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