This application requests support for a predoctoral Training Program in Cellular, Biochemical and Molecular Sciences at Thomas Jefferson University. This Program provides students with broad multidisciplinary training in using biochemical, cellular and molecular strategies to address important biological questions. All mentors in this program have established research programs and significant experience in mentoring. Specific training areas include growth factor, G protein-coupled and nuclear receptor signaling, signal integration, protein targeting and trafficking, cell cycle regulation, apoptosis, transcription and DNA repair. Ongoing research projects address the importance of these areas to normal functioning as well as to disease processes and therapeutic inventions. In addition, a significant number of the mentors use animal models and translational approaches in their research. This unique combination of participating faculty will provide training through course work, direct mentoring interactions, specialized educational activities, seminars and semi-annual retreats. The Training Program in Cellular, Biochemical and Molecular Sciences includes 25 mentors from 7 basic and clinical departments and is administered by the Principal Investigator and Administrative Committees. The leadership team is focused on delivering training excellence to an ethnically and scientifically diverse cadre of trainees. The program will be evaluated through both internal and external review mechanisms to ensure that the trainees are receiving the best possible training experience. Overall, this Program will provide outstanding career development for trainees to pursue careers dependent on knowing how to use mechanistic approaches to address important scientific questions and it will provide a critical team educational experience in the multidisciplinary nature of using animal models and translational approaches to understand disease.

Public Health Relevance

The overall goal of this training program is to develop highly trained research scientists who understand how to address important scientific questions and are ready to pursue careers as independent investigators. The program also provides trainees with an understanding of the mechanisms involved in health and disease, giving our training program high relevance to public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM100836-04
Application #
8881217
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
2012-07-01
Project End
2016-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
4
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Rogers, Corey; Fernandes-Alnemri, Teresa; Mayes, Lindsey et al. (2017) Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nat Commun 8:14128
Sankhala, Rajeshwer S; Lokareddy, Ravi K; Begum, Salma et al. (2017) Three-dimensional context rather than NLS amino acid sequence determines importin ? subtype specificity for RCC1. Nat Commun 8:979
Carr 3rd, Richard; Koziol-White, Cynthia; Zhang, Jie et al. (2016) Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms. Mol Pharmacol 89:94-104
Carr 3rd, Richard; Schilling, Justin; Song, Jianliang et al. (2016) ?-arrestin-biased signaling through the ?2-adrenergic receptor promotes cardiomyocyte contraction. Proc Natl Acad Sci U S A 113:E4107-16
Carr 3rd, Richard; Benovic, Jeffrey L (2016) From biased signalling to polypharmacology: unlocking unique intracellular signalling using pepducins. Biochem Soc Trans 44:555-61
L Black, Kathryn; Petruk, Svetlana; Fenstermaker, Tyler K et al. (2016) Chromatin proteins and RNA are associated with DNA during all phases of mitosis. Cell Discov 2:16038
Rouleau, Lauren; Antony, Anil Noronha; Bisetto, Sara et al. (2016) Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity. Free Radic Biol Med 95:308-322
Lokareddy, Ravi K; Hapsari, Rizqiya A; van Rheenen, Mathilde et al. (2015) Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure 23:1305-1316
Kang, Seokwon; Fernandes-Alnemri, Teresa; Rogers, Corey et al. (2015) Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun 6:7515
Augello, Michael A; Berman-Booty, Lisa D; Carr 3rd, Richard et al. (2015) Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med 7:628-47

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