The complex biomedical, psychological, neuropsychiatric, psychosocial, and sociocultural challenges associated with the HIV/AIDS epidemic are such that there continues to be a critical need for specialists in HIV/AIDS clinical research. This application proposes the development of a training program to provide comprehensive postdoctoral clinical research training in the HIV/AIDS mental health and behavioral science arena for psychiatrists and clinical psychologists. Through the creation of a training infrastructure consisting of an interdisciplinary collaborative faculty, the program would: (1) provide broad HIV/AIDS clinical research training through didactic seminars and involvement in research projects, and (2) offer specialized training along one of three pathways: applied mental health research, behavioral interventions research, or research linking basic science investigation to clinical areas. The program will be located in the Emory University Department of Psychiatry and Behavioral Sciences with key training linkages throughout the Emory University School of Medicine, Rollins School of Public Health, Yerkes Regional Primate Research Center, Centers for Disease Control and Prevention, and Georgia State University. The diversity of the program faculty and resources permit innovative research pursuits with clinically, ethnically, and culturally diverse populations of HIV-seropositive and HIV-affected individuals and groups. The overall goal of the proposed clinical research training program is to train clinical researchers who could then meaningfully contribute to the future scientific agenda for HIV/AIDS mental health and behavioral science research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH020018-05
Application #
6538512
Study Section
Clinical AIDS and Immunology Review Committee (CAIR)
Program Officer
Chavez, Mark
Project Start
1998-07-01
Project End
2003-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
5
Fiscal Year
2002
Total Cost
$190,221
Indirect Cost
Name
Emory University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Felger, Jennifer C; Haroon, Ebrahim; Woolwine, Bobbi J et al. (2016) Interferon-alpha-induced inflammation is associated with reduced glucocorticoid negative feedback sensitivity and depression in patients with hepatitis C virus. Physiol Behav 166:14-21
Felger, Jennifer C; Hernandez, Carla R; Miller, Andrew H (2015) Levodopa reverses cytokine-induced reductions in striatal dopamine release. Int J Neuropsychopharmacol 18:
Felger, Jennifer C; Mun, Jiyoung; Kimmel, Heather L et al. (2013) Chronic interferon-? decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates. Neuropsychopharmacology 38:2179-87
Felger, Jennifer C; Miller, Andrew H (2012) Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol 33:315-27
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Felger, Jennifer C; Alagbe, Oyetunde; Pace, Thaddeus W W et al. (2011) Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue. Brain Behav Immun 25:1094-8
Shelton, Richard C; Miller, Andrew H (2010) Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Prog Neurobiol 91:275-99
Raison, Charles L; Rye, David B; Woolwine, Bobbi J et al. (2010) Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biol Psychiatry 68:942-9
Raison, C L; Dantzer, R; Kelley, K W et al. (2010) CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 15:393-403
Miller, Andrew H (2009) Norman Cousins Lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface. Brain Behav Immun 23:149-58

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