The complex biomedical, psychological, neuropsychiatric, psychosocial, and sociocultural challenges associated with the HIV/AIDS epidemic are such that there continues to be a pressing need for specialists in HIV/AIDS clinical behavioral research. The purpose of the proposed T32 program is to provide comprehensive postdoctoral clinical research training in HIV/AIDS mental health and behavioral science for psychiatrists and clinical psychologists. Through the creation of a training infrastructure consisting of an interdisciplinary collaborative faculty, the program: (1) provides broad HIV/AIDS clinical research training through didactic seminars and involvement in research projects, and (2) offers specialized training along one of two pathways: applied/translational mental health research and behavioral prevention/intervention research. The program is located in the Emory University Department of Psychiatry and Behavioral Sciences with key training linkages to the Emory University School of Medicine, Rollins School of Public Health, Yerkes Regional Primate Research Center, the Centers for Disease Control and Prevention, and Georgia State University. The program also capitalizes on the vast resources of the Emory Center for AIDS Research. The diversity of the program permits research pursuits with clinically, ethnically, and culturally diverse populations of HIV seropositive and HIV affected individuals and groups, including African Americans, adolescents, prison populations, individuals with substance use disorders, and populations in underdeveloped countries. In addition, special areas of expertise of program faculty in brain imaging, psychoneuroendocrinology/immunology, psychopharmacology and HIV/AIDS clinical trials provide unique opportunities for research training in the pathology and treatment of neuropsychiatric complications related to HIV/AIDS. The ultimate goal of the clinical research training program is to train clinical researchers who can meaningfully contribute to the scientific agenda for HIV/AIDS mental health and behavioral science research. Special emphasis in the revised application is placed on the development of hypothesis-driven research grants (in the first year), followed by an emphasis on the professional skills required for transitioning into an academic position post graduation. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH020018-09
Application #
7257062
Study Section
Special Emphasis Panel (ZMH1-CRB-C (03))
Program Officer
Stoff, David M
Project Start
1998-07-01
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
9
Fiscal Year
2007
Total Cost
$192,253
Indirect Cost
Name
Emory University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Felger, Jennifer C; Haroon, Ebrahim; Woolwine, Bobbi J et al. (2016) Interferon-alpha-induced inflammation is associated with reduced glucocorticoid negative feedback sensitivity and depression in patients with hepatitis C virus. Physiol Behav 166:14-21
Felger, Jennifer C; Hernandez, Carla R; Miller, Andrew H (2015) Levodopa reverses cytokine-induced reductions in striatal dopamine release. Int J Neuropsychopharmacol 18:
Felger, Jennifer C; Mun, Jiyoung; Kimmel, Heather L et al. (2013) Chronic interferon-? decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates. Neuropsychopharmacology 38:2179-87
Felger, Jennifer C; Miller, Andrew H (2012) Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol 33:315-27
Felger, J C; Cole, S W; Pace, T W W et al. (2012) Molecular signatures of peripheral blood mononuclear cells during chronic interferon-? treatment: relationship with depression and fatigue. Psychol Med 42:1591-603
Felger, Jennifer C; Alagbe, Oyetunde; Pace, Thaddeus W W et al. (2011) Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue. Brain Behav Immun 25:1094-8
Raison, Charles L; Rye, David B; Woolwine, Bobbi J et al. (2010) Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biol Psychiatry 68:942-9
Raison, C L; Dantzer, R; Kelley, K W et al. (2010) CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 15:393-403
Shelton, Richard C; Miller, Andrew H (2010) Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Prog Neurobiol 91:275-99
Miller, Andrew H (2009) Norman Cousins Lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface. Brain Behav Immun 23:149-58

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