The NIDDK Liver Transplantation Database (LTD) is a multicenter registry of more than 1500 consecutive candidates for liver transplantation (LT), recruited between 1990 and 1994, by three major liver transplant centers in the United States. As such, it is the only scientifically designed and implemented multicenter study from which the recent experience of a large cohort of LT candidates and recipients in this country can be rigorously analyzed. The effort to build this detailed and high quality resource was carried out under a 7-year NIDDK contract which ends in December 1997. Valuable information collected in this study includes clinical and laboratory data collected by protocol and at a time of events, and it is enriched with protocol biopsies from a high proportion of recipients, a bank of serial serum specimens, and a virtual tissue bank. Since the current contract only provided for follow-up of 3 years on average, the range of topics that could be investigated, using this comprehensive data base, is limited. The current plan is to continue the follow-up of the cohort of transplant recipients for another 5 years through the next phase of the post-transplantation period, when recurrence of the original disease and long-term adverse effects of immunosuppression and re-transplantation are most likely to occur. Thus, the Coordinating Center, with the support of the investigators of the three LTD clinical centers, will be able to obtain complete follow-up for an average of 10 years (8-12 years) to observe the information recorded in the study before, during an dafter transplantation. The proposed effort is expected to yield results of great scientific and clinical importance which could directly influence future transplant candidate selection and post-transplantation patient management.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DK055883-02S1
Application #
6318636
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Everhart, James
Project Start
1998-09-01
Project End
2003-08-31
Budget Start
2000-07-15
Budget End
2000-08-31
Support Year
2
Fiscal Year
2000
Total Cost
$23,913
Indirect Cost
Name
University of Pittsburgh
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Ruppert, Kristine; Kuo, Shihchen; DiMartini, Andrea et al. (2010) In a 12-year study, sustainability of quality of life benefits after liver transplantation varies with pretransplantation diagnosis. Gastroenterology 139:1619-29, 1629.e1-4
Watt, K D S; Pedersen, R A; Kremers, W K et al. (2010) Evolution of causes and risk factors for mortality post-liver transplant: results of the NIDDK long-term follow-up study. Am J Transplant 10:1420-7
Watt, Kymberly D S; Pedersen, Rachel A; Kremers, Walter K et al. (2009) Long-term probability of and mortality from de novo malignancy after liver transplantation. Gastroenterology 137:2010-7
Balan, Vijayan; Ruppert, Kris; Demetris, A Jake et al. (2008) Long-term outcome of human leukocyte antigen mismatching in liver transplantation: results of the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database. Hepatology 48:878-88
Evans, Idris V R; Belle, Steven H; Wei, Yuling et al. (2005) Post-transplantation growth among pediatric recipients of liver transplantation. Pediatr Transplant 9:480-5
Charlton, Michael; Ruppert, Kris; Belle, Steven H et al. (2004) Long-term results and modeling to predict outcomes in recipients with HCV infection: results of the NIDDK liver transplantation database. Liver Transpl 10:1120-30