Abstract

The goal of this research is to better understand the metabolic state of cells that are deprived of oxygen. In this initial pilot project phase we will adapt methods for analyzing metabolism energetics and oxidative damage to studying the model organism zebrafish (Danio rerio). We will apply these methods; 1. To determine the response of the metabolism and intracellular energetics of zebrafish embryos to varying oxygen tensions at different periods in development. 2. To define the extent of oxidative damage that results from alterations in the oxygen levels. 3. To develop and begin to test hypotheses about mechanisms of surviving hypoxia that may be common to zebrafish and tumors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants--Cooperative Agreements (U56)
Project #
1U56CA096286-01
Application #
6606809
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2002-06-12
Project End
2007-05-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
New Mexico State University Las Cruces
Department
Type
DUNS #
City
Las Cruces
State
NM
Country
United States
Zip Code
88003

  Publications

Thompson, Beti; O'Connell, Mary; Löest, Helena et al. (2013) Understanding and reducing obstacles in a collaboration between a minority institution and a cancer center. J Health Care Poor Underserved 24:1648-56
Unguez, Graciela A (2013) Electric fish: new insights into conserved processes of adult tissue regeneration. J Exp Biol 216:2478-86
Voorhies, Wayne A Van (2012) Robust metabolic responses to varied carbon sources in natural and laboratory strains of Saccharomyces cerevisiae. PLoS One 7:e30053
Weber, Christopher M; Martindale, Mark Q; Tapscott, Stephen J et al. (2012) Activation of Pax7-positive cells in a non-contractile tissue contributes to regeneration of myogenic tissues in the electric fish S. macrurus. PLoS One 7:e36819
Icreverzi, Amalia; de la Cruz, Aida Flor; Van Voorhies, Wayne A et al. (2012) Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress. Cell Cycle 11:554-68
Vermillion, Karl; Holguin, F Omar; Berhow, Mark A et al. (2011) Dinoxin B, a withanolide from Datura inoxia leaves with specific cytotoxic activities. J Nat Prod 74:267-71
Celotto, Alicia M; Chiu, Wai Kan; Van Voorhies, Wayne et al. (2011) Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction. PLoS One 6:e25823
Siamakpour-Reihani, Sharareh; Peterson, Tabitha A; Bradford, Andrew M et al. (2011) Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation. J Mol Recognit 24:314-21
Pias, Sally; Peterson, Tabitha A; Johnson, Dennis L et al. (2010) The intertwining of structure and function: proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation. Crit Rev Immunol 30:299-304
Coronado, Gloria D; O'Connell, Mary A; Anderson, Jennifer et al. (2010) Undergraduate cancer training program for underrepresented students: findings from a minority institution/cancer center partnership. J Cancer Educ 25:32-5

Showing the most recent 10 out of 25 publications