Abstract

This application, in response to RFA TR-12-006: Institutional Clinical and Translational Science Award (U54), requests support for the University of Utah's Center for Clinical and Translational Science (CCTS). Our CCTS is built upon the UU's historic strengths in genetics and bioinformatics. Our vision for the next five years is to maintain and leverage the service cores of the CCTS and use that infrastructure as a springboard to launch new programs. With implementation of this vision we will fulfill the Aims of the CTSA described in the FOA by maintaining a home for translational research to: (1) Increase the quality, quantity, safety, efficiency, and impact of translational research for all conditions; (2) Provide resources and services to support and speed the planning and implementation of clinical and translational research across the entire range of research and communities; (3) Train, mentor, and support the next generation of translational investigators through the stage of becoming principal investigators and productive faculty members; (4) Maintain a governance structure that represents the full spectrum of translational science and all of its stakeholders to effectively fulfill the Aims; (5) Engage in a process of continuous evaluation, improvement, and innovation in all of these areas. The mission of the UU CCTS will be to provide support for all aspects of translational research. Even support that can be characterized as service will be used to inform innovation and catalyze new thinking. In addition, we will direct new resources toward providing special expertise to the CTSA consortium in specific areas, namely: Human genetics; genotype/phenotype correlation; health services research including comparative effectiveness; medical device innovation, and; taking the electronic medical record to the next level as a tool for medical care and medical research. We will continue to perform research aimed at re-engineering the process of translational investigation.

Public Health Relevance

; Providing resources and services to support and speed the planning and implementation of clinical and translational research across the entire range of research and communities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR001067-04S1
Application #
9313437
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Brazhnik, Olga
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2016-08-01
Budget End
2017-04-30
Support Year
4
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Blaschke, Anne J; Korgenski, E Kent; Wilkes, Jacob et al. (2018) Rhinovirus in Febrile Infants and Risk of Bacterial Infection. Pediatrics 141:
Campbell, Robert A; Franks, Zechariah; Bhatnagar, Anish et al. (2018) Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging. J Immunol 200:295-304
Hung, Man; Xu, Julie; Nielson, Dominique et al. (2018) Evaluating the Prediction of Breast Cancer Survival Using Lymph Node Ratio. J Breast Cancer 21:315-320
Swords, Douglas S; Zhang, Chong; Presson, Angela P et al. (2018) Association of time-to-surgery with outcomes in clinical stage I-II pancreatic adenocarcinoma treated with upfront surgery. Surgery 163:753-760
Rothwell, Erin; Botkin, Jeffrey R; Cheek-O'Donnell, Sydney et al. (2018) An empirical assessment of the short-term impacts of a reading of Deborah Zoe Laufer's drama Informed Consent on attitudes and intentions to participate in genetic research. AJOB Empir Bioeth 9:69-76
Thomas, Alun; Khader, Karim; Redd, Andrew et al. (2018) Extended models for nosocomial infection: parameter estimation and model selection. Math Med Biol 35:29-49
Chow, Candace J; Byington, Carrie L; Olson, Lenora M et al. (2018) A Conceptual Model for Understanding Academic Physicians' Performances of Identity: Findings From the University of Utah. Acad Med 93:1539-1549
Kazmers, Nikolas H; Presson, Angela P; Xu, Yizhe et al. (2018) Cost Implications of Varying the Surgical Technique, Surgical Setting, and Anesthesia Type for Carpal Tunnel Release Surgery. J Hand Surg Am 43:971-977.e1
Hanson, Heidi A; Hay Jr, William W; Tobin, Jonathan N et al. (2018) Opportunities for life course research through the integration of data across Clinical and Translational Research Institutes. J Clin Transl Sci 2:156-162
Chen, Jiun-Sheng; Hu, Fulan; Kugathasan, Subra et al. (2018) Targeted Gene Sequencing in Children with Crohn's Disease and Their Parents: Implications for Missing Heritability. G3 (Bethesda) 8:2881-2888

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