Abstract

: The Oswaldo Cruz Foundation (FIOCRUZ) Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials), is a multidisciplinary, integrated research center based in Rio de Janeiro, Brazil that is partnered with the Institute de Pesquisa Clinica Evandro Chagas Clinical Research Site (IPEC CRS), Together the FioTrials CTU and IPEC CRS provide care for both at-risk and HIV infected persons and cater to the needs of certain disenfranchised populations, including men who have sex with men (MSM), transgender women, racial minorities, women, and those who are poverty stricken and/or uneducated. The FioTrials CTU and IPEC CRS have unique strengths to offer the AIDS Clinical Trials Group (ACTG), HIV Prevention Trials Network (HPTN) and Microbicide Trials Network (MTN), including a cadre of leading researchers; a partnership with FIOCRUZ, an internationally-recognized governmental organization dedicated to public health research; and a participant population that compliments the scientific agendas of each network. The goal of our research is to 1) evaluate and implement integrated strategies (therapeutic and behavioral) to prevent HIV acquisition in MSM, transgender women and women; 2) evaluate the safety, efficacy and utility of rectal microbicides for our MSM population; 3) evaluate novel diagnostics, technologies, prevention and treatment interventions for tuberculosis in HIV co-infected individuals; 4) evaluate novel treatment strategies for hepatitis C, particularly for those with HI co-infection; and 5) assess novel therapeutics and improve existing HIV treatment strategies and prevent co-morbidities. Achievement of these objectives will be attributed to the outstanding infrastructure of the FioTrials CTU, its CRS and its community-focused research strategies.

Public Health Relevance

The FioTrials CTU will continue to make significant contributions to the fight against the HIV/AIDS and tuberculosis epidemics in Brazil and throughout Latin America, particularly for the population of MSM and transgender women who are the most heavily affected by the burden of HIV in Brazil.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
5UM1AI069476-12
Application #
9605062
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Roby, Gregg A,
Project Start
2008-01-15
Project End
2020-11-30
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
12
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Fundacao Oswaldo Cruz
Department
Type
DUNS #
899294177
City
Rio de Janeiro
State
Country
Brazil
Zip Code
21040-360

  Publications

Adachi, Kristina; Xu, Jiahong; Ank, Bonnie et al. (2018) Congenital CMV and HIV Perinatal Transmission. Pediatr Infect Dis J :
Ngongondo, McNeil; Miyahara, Sachiko; Hughes, Michael D et al. (2018) Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial. J Acquir Immune Defic Syndr 78:54-61
Torres, Thiago S; Harrison, Linda J; La Rosa, Alberto M et al. (2018) Quality of life improvement in resource-limited settings after one year of second-line antiretroviral therapy use among adult men and women. AIDS 32:583-593
Caniglia, Ellen C; Phillips, Andrew; Porter, Kholoud et al. (2018) Commonly Prescribed Antiretroviral Therapy Regimens and Incidence of AIDS-Defining Neurological Conditions. J Acquir Immune Defic Syndr 77:102-109
Luz, Paula M; Benzaken, Adele; Alencar, Tatianna M de et al. (2018) PrEP adopted by the brazilian national health system: What is the size of the demand? Medicine (Baltimore) 97:S75-S77
Poynard, Thierry; Munteanu, Mona; Charlotte, Frederic et al. (2018) Impact of steatosis and inflammation definitions on the performance of NASH tests. Eur J Gastroenterol Hepatol 30:384-391
De Boni, Raquel B; Lentini, Nena; Santelli, Ana Cfs et al. (2018) Self-testing, communication and information technology to promote HIV diagnosis among young gay and other men who have sex with men (MSM) in Brazil. J Int AIDS Soc 21 Suppl 5:e25116
Carriquiry, Gabriela; Giganti, Mark J; Castilho, Jessica L et al. (2018) Virologic failure and mortality in older ART initiators in a multisite Latin American and Caribbean Cohort. J Int AIDS Soc 21:e25088
Adachi, Kristina; Xu, Jiahong; Yeganeh, Nava et al. (2018) Combined evaluation of sexually transmitted infections in HIV-infected pregnant women and infant HIV transmission. PLoS One 13:e0189851
Fink, Valeria I; Jenkins, Cathy A; Castilho, Jessica L et al. (2018) Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America. Infect Agent Cancer 13:16

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