In this proposal we provide a rationale for continued infrastructure support for two established, population based cancer epidemiology cohorts that enrolled 81,501 Chinese men and women at baseline in the late 1980s in Shanghai and in the early 1990s in Singapore. Infrastructure support is needed to accrue an additional 2,700 new cancer cases over the next five years to accomplish the overall goal of conducting innovative research that evaluates how environmental and lifestyle exposures, and genetic susceptibility together affect cancer incidence, mortality and aging-related outcomes. In addition to collecting questionnaire information, these two Asian cohorts include an established biorepository with blood, buccal and urine samples from more than 50,000 participants. With the vigorous follow-up procedures in place, only 1.5 percent of the original cohort participants have been lost to follow-up. To date, approximately 17 percent of the cohort members were diagnosed with incident cancers;approximately 50 percent of the cancer patients have stored biospecimens. Researches evaluating the unique environmental and lifestyle exposures of the Asian cohort study populations have provided novel findings that contributed to the field of cancer etiology and prevention. These novel findings in part provided the rationale for our current chemoprevention trials in U.S. populations. During the next 5-year study period, we propose to: (1) Conduct core infrastructure activities to maintain and enhance the two Asian cohort databases, including: (a) follow-up for cancer, non-cancer and death outcomes, (b) maintenance of the biorepositories, and (c) management of the databases;(2) Conduct in-person and telephone interviews among cohort participants to update exposure and medical information;(3) Collect blood and urine samples from cohort participants with cancer diagnoses;and (4) Engage in collaborative research projects of the NCI and Asian Consortium Consortia. We anticipate that the established resources of the two Asian cohorts will become even more scientifically valuable over the next five years as the younger members of the cohorts enter into the age of maximal cancer incidence, thereby increasing the number of pre-disease biomarker-based research projects.

Public Health Relevance

We are requesting infrastructure support for two established, population-based cancer epidemiology cohorts among Chinese men and women. The unique exposures and cancer risl

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
1UM1CA182876-01A1
Application #
8762819
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (M1))
Program Officer
Mahabir, Somdat
Project Start
2014-09-16
Project End
2019-08-31
Budget Start
2014-09-16
Budget End
2015-08-31
Support Year
1
Fiscal Year
2014
Total Cost
$880,000
Indirect Cost
$182,287
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Yuan, Jian-Min; Beckman, Kenneth B; Wang, Renwei et al. (2018) Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study. Int J Cancer 142:2234-2243
Wang, Zhensheng; Koh, Woon-Puay; Jin, Aizhen et al. (2018) Telomere length and risk of developing gastric adenocarcinoma: The Singapore Chinese Health Study. Gastric Cancer 21:598-605
Dai, Zhaoli; Jin, Aizhen; Soh, Avril Zixin et al. (2018) Coffee and tea drinking in relation to risk of hip fracture in the Singapore Chinese Health Study. Bone 112:51-57
Wang, Yeli; Meng, Rui-Wei; Kunutsor, Setor K et al. (2018) Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis. Sci Rep 8:406
Koh, Angela S; Gao, Fei; Leng, Shuang et al. (2018) Dissecting Clinical and Metabolomics Associations of Left Atrial Phasic Function by Cardiac Magnetic Resonance Feature Tracking. Sci Rep 8:8138
Chang, Xuling; Dorajoo, Rajkumar; Sun, Ye et al. (2018) Gene-diet interaction effects on BMI levels in the Singapore Chinese population. Nutr J 17:31
Soh, Avril Z; Chee, Michael W L; Yuan, Jian-Min et al. (2018) Sleep lengthening in late adulthood signals increased risk of mortality. Sleep 41:
Ferreiro-Iglesias, Aida; Lesseur, Corina; McKay, James et al. (2018) Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity. Nat Commun 9:3927
Thean, Lai Fun; Low, Yee Syuen; Lo, Michelle et al. (2018) Genome-wide association study identified copy number variants associated with sporadic colorectal cancer risk. J Med Genet 55:181-188
Chei, Choy-Lye; Loh, Julian Kenrick; Soh, Avril et al. (2018) Coffee, tea, caffeine, and risk of hypertension: The Singapore Chinese Health Study. Eur J Nutr 57:1333-1342

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