This clinical protocol will examine measures of heart rate variability (HRV) in male and female alcoholics admitted for drinking cessation continuously and non-invasively. These measures will be compared and contrasted with HRV parameters studied in healthy comparison subjects. Inter-beat interval (IBI) will be measured in patients for 3 consecutive 96 hours periods every 7 days during the course of treatment. Coarse-graining spectral analysis (CGSA) will be utilized to simultaneously evaluate parasympathetic (PNS) and sympathetic (SNS) nervous system indicators, and a measure of signal complexity and variability.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000092-01
Application #
2456604
Study Section
Special Emphasis Panel (LCS)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Karimullah, K; George, D T; DePetrillo, P B (2001) The time-course of electrocardiographic interbeat interval dynamics in alcoholic subjects after short-term abstinence. Eur J Pharmacol 427:227-33
DePetrillo, P B; Bennett, A J; Speers, D et al. (2000) Ondansetron modulates pharmacodynamic effects of ketamine on electrocardiographic signals in rhesus monkeys. Eur J Pharmacol 391:113-9
DePetrillo, P B; White, K V; Liu, M et al. (1999) Effects of alcohol use and gender on the dynamics of EKG time-series data. Alcohol Clin Exp Res 23:745-50