During the present report period, antitumor and anti-HIV bioassay-guided fractionation has led to a variety of structurally and biologically intriguing new active chemotypes from marine animals and terrestrial plants. Efforts have been focused predominantly upon the following: tubulin-interactive compounds from Phyllanthus mirabilis and Polymnia fruticoso; cytotoxic saponins from legumes (fam. Leguminosae/Fabaceae/Mimosaceae); development of dereplication methodologies for anti-HIV phorbols from extracts of plants of the family Euphorbiaceae/Thymelaeaceae; and, anti-HIV and cytotoxic constituents from Buchenavia capitata.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CM007329-01
Application #
3838167
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Division of Cancer Treatment
Department
Type
DUNS #
City
State
Country
United States
Zip Code