Assistance was provided to researchers from NCI and other institutions on the design and statistical analysis of a broad range of laboratory studies including: host cell reactivation studies in the Dermatology Branch to examine whether patients with Alzheimer disease are defective in the repair of DNA damage induced by oxygen radicals; an investigation carried out by the Laboratory of Molecular Carcinogenesis using UV-induced mutations in transfected plasmids to evaluate possible hypermutability of cells from patients with Dysplastic Nevus Syndrome or familial melanoma; a study of transplacental effects of AZT in rodents by the Laboratory of Chemical Carcinogenesis and Tumor Promotion; an investigation of polymorphic variation in the XPC gene by the Laboratory of Molecular Carcinogenesis using a recently identified marker allele with a poly-AT insertion; a study performed in the Laboratory of Genetics of plasmacytoma incidence rates in mice administered the cyclo-oxygenase inhibitor, indomethacin; experiments in the Laboratory of Molecular Biology comparing tumor rates and cell division rates in transgenic and wild type mice; an investigation in the Chemoprevention Branch to examine the effectiveness of certain polyphenols in tea extracts to prevent chromatid damage in cultured cells exposed to ionizing radiation; a study with the Laboratory of Human Carcinogenesis of the p53 mutational spectrum in bladder cancers following treatment with cyclophosphamide; an investigation in the Laboratory of Human Carcinogenesis examining evolutionary conservation of p53 mutational hot spots; an investigation in the Laboratory of Molecular Genetics of the NIA demonstrating an excess of tandem mutations in immunoglobulin genes of PMS2 knockout mice; a study by the Laboratory of Molecular Genetics of the NIA measuring the quantity of various types of oxidative DNA damage in fibroblasts obtained from Cockayne's syndrome patients; a study by the University of Minnesota Laboratory of Environmental Medicine and Pathology of chromosome damage and hormone levels in pesticide appliers.
| Behrens, C; Travis, L B; Wistuba, I I et al. (2000) Molecular changes in second primary lung and breast cancers after therapy for Hodgkin's disease. Cancer Epidemiol Biomarkers Prev 9:1027-35 |
| Tawn, E J; Whitehouse, C A; Holdsworth, D et al. (2000) Chromosome analysis of workers occupationally exposed to radiation at the Sellafield nuclear facility. Int J Radiat Biol 76:355-65 |
| Khan, S G; Metter, E J; Tarone, R E et al. (2000) A new xeroderma pigmentosum group C poly(AT) insertion/deletion polymorphism. Carcinogenesis 21:1821-5 |
| Garry, V F; Burroughs, B; Tarone, R et al. (1999) Herbicides and adjuvants: an evolving view. Toxicol Ind Health 15:159-67 |
| Walker, D R; Bond, J P; Tarone, R E et al. (1999) Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features. Oncogene 18:211-8 |
