The mu opiate receptor (OR) has been identified as the principal brain receptor site best correlated with the rewarding and euphoric properties of opiate drugs. This year investigators in this Branch have continued with vastly-reduced work with mu receptor knockout mice and phosphoregulation of the muOR due to personnel attenuation. Work on mu knockout mice during this year continued to document modest effects of mu knockout on several intersting features, including the relative robustness of the mu knockout effects to genetic background and effects of mu deletion on reward phenotypes from more and more drugs. During this year these investigators identified mu receptor region haplotypes associated with addiction vulnerability in several different human ganome scanning samples.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Intramural Research (Z01)
Project #
1Z01DA000406-08
Application #
7149294
Study Section
(MNRB)
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2005
Total Cost
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Hashimoto, Keisuke; Amano, Taku; Kasakura, Akiko et al. (2009) mu-Opioid receptor-independent fashion of the suppression of sodium currents by mu-opioid analgesics in thalamic neurons. Neurosci Lett 453:62-7
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