Abstract

The mu opiate receptor (OR) has been identified as the principal brain receptor site best correlated with the rewarding and euphoric properties of opiate drugs. Study of this gene in humans and mouse models will help understand the roles of the gene and its variants in a number of interesting behaviors and other phenotypes. This year investigators in this Branch have continued with vastly-reduced work with mu receptor knockout mice and the human OPRM1 locus due to personnel attenuation. Work on mu knockout mice during this year continued to document modest effects of mu knockout on several intersting features that include hippocampal neurogenesis and ethanol-relted dopamine efflux while studies of strain differences in levels of OPRM1 expression have resulted in identificaiton of a molecular mechanism for these differences that involves an intracisternal particle insertion near this site in an underexpressin strain.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Intramural Research (Z01)
Project #
1Z01DA000406-10
Application #
7593254
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2007
Total Cost
$105,856
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Hashimoto, Keisuke; Amano, Taku; Kasakura, Akiko et al. (2009) mu-Opioid receptor-independent fashion of the suppression of sodium currents by mu-opioid analgesics in thalamic neurons. Neurosci Lett 453:62-7
Ide, Soichiro; Minami, Masabumi; Ishihara, Kumatoshi et al. (2008) Abolished thermal and mechanical antinociception but retained visceral chemical antinociception induced by butorphanol in micro-opioid receptor knockout mice. Neuropharmacology 54:1182-8
Harburg, G C; Hall, F S; Harrist, A V et al. (2007) Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons. Neuroscience 144:77-87
Job, Martin O; Tang, Amanda; Hall, F Scott et al. (2007) Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis. Biol Psychiatry 62:627-34
Han, Wenhua; Hata, Harumi; Imbe, Hiroki et al. (2006) Increased body weight in mice lacking mu-opioid receptors. Neuroreport 17:941-4
Wu, Hsiang-en; Sun, Han-Sen; Terashivili, Maia et al. (2006) dextro- and levo-morphine attenuate opioid delta and kappa receptor agonist produced analgesia in mu-opioid receptor knockout mice. Eur J Pharmacol 531:103-7
Yamada, Hiroaki; Shimoyama, Naohito; Sora, Ichiro et al. (2006) Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors. Brain Res 1083:61-9
Ide, Soichiro; Minami, Masabumi; Ishihara, Kumatoshi et al. (2006) Mu opioid receptor-dependent and independent components in effects of tramadol. Neuropharmacology 51:651-8
Kasai, Shinya; Han, Wenhua; Ide, Soichiro et al. (2006) Involvement of the 3' non-coding region of the mu opioid receptor gene in morphine-induced analgesia. Psychiatry Clin Neurosci 60 Suppl 1:S11-7
Han, Wenhua; Kasai, Shinya; Hata, Harumi et al. (2006) Intracisternal A-particle element in the 3' noncoding region of the mu-opioid receptor gene in CXBK mice: a new genetic mechanism underlying differences in opioid sensitivity. Pharmacogenet Genomics 16:451-60

Showing the most recent 10 out of 18 publications