In an attempt to devise more effective methods for treatment of epilepsy that is intractible to conventional, modern medical therapy or surgical intervention, we are exploring the feasibility of brain grafts of GABAergic brain tissue to effected brain areas in rat models of epilepsy. We have developed two satisfactory experimental epilepsy models in the laboratory, the audiogenic seizures in a genetically pre-disposed strain of rats and amygdala kindling. Successful grafts of fetal cerebellar tissue to adult rat ventricles has been accomplished.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002274-01
Application #
4696535
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code