In an attempt to devise more effective methods for treatment of epilepsy that is intractable to conventional modern medical therapy or surgical intervention, we are exploring the feasibility of brain grafts of GABAergic brain tissue to affected brain areas in rat models of epilepsy. We have developed two satisfactory experimental epilepsy models in the laboratory: (1) audiogenic seizures in genetically predisposed rats and amygdala kindling. Grafts of fetal cerebellar tissue are being placed in critical sites where GABAergic agents have been shown to arrest seizures.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002274-02
Application #
3968580
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code