We have measured regional cerebral blood flow (rCBF) with oxygen-15 and positron emission tomography in young normal subjects during performance of a battery of frontal lobe tasks putatively involving working memory as well as during performance of matched sensorimotor control tasks for each frontal lobe task. The results indicate that the physiological concomitants of working memory in man include activation of the dorsolateral prefrontal cortex. Among the brain areas studied to date, this activation is localized to the inferior frontal gyrus in slices falling between six to eight centimeters above the canthomeatal line.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002576-01
Application #
3860023
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code