We have measured regional cerebral blood flow (rCBF) with oxygen-15 and positron emission tomography in young normal subjects during performance of a battery of frontal lobe tasks putatively involving working memory as well as during performance of matched sensorimotor control tasks for each frontal lobe task. The results indicate that tasks involving working memory activate a network including dorsolateral prefrontal and parietal cortical areas in humans. Among the brain areas studied to date, this activation is localized to the inferior frontal gyrus in slices falling between six to eight centimeters above the canthomeatal line and parietal cortex eight to 10 centimeters above the canthomeatal line.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002576-02
Application #
3845358
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code