Funding of all LCNSS research has been terminated, with the result that no experimental data has been generated during the past year. Nevertheless, the following 5 experiments (funded by the private sector or university medical centers) are either in progress or in preparation on off-campus sites: 1. Bioassay in mice of blood component infectivity in a mouse-adapted strain of variant CJD. 2. Bioassay in squirrel monkeys of blood component infectivity in human patients with either sporadic or variant Creutzfeldt-Jakob disease (CJD). 3. Inactivation of scrapie agent under incineration conditions of 600?C and 1000?C, assaying infectivity in both the ashed residue and vented flu gas. 4. Inactivation of scrapie agent using commercial technology of multiple ultra-high pressure pulsation. 5. Bioassay of total volume inoculations of serial dilutions of scrapie and CJD to determine if infectivity can be diluted to extinction. Note: the bibliography section is massively incomplete, as Pub Med has missed numerous articles published in many different journals, and there is no appropriate choice with which to complete the listing.
| Artwohl, James; Brown, Patricia; Corning, Brian et al. (2006) Report of the ACLAM Task Force on Rodent Euthanasia. J Am Assoc Lab Anim Sci 45:98-105 |
| Grosse, Pascal; Edwards, M; Tijssen, M A J et al. (2004) Patterns of EMG-EMG coherence in limb dystonia. Mov Disord 19:758-69 |
| Strens, L H A; Asselman, P; Pogosyan, A et al. (2004) Corticocortical coupling in chronic stroke: its relevance to recovery. Neurology 63:475-84 |
| Brown, P Leon; Kiyatkin, Eugene A (2004) Brain hyperthermia induced by MDMA (ecstasy): modulation by environmental conditions. Eur J Neurosci 20:51-8 |
| Liberski, Pawel P; Sikorska, Beata; Bratosiewicz-Wasik, Jolanta et al. (2004) Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy. Int J Biochem Cell Biol 36:2473-90 |
| Zhang, Jianxing; Jeremy Woods, R; Brown, Phillip B et al. (2004) Photochemical tissue bonding using monomeric 4-amino-1,8-naphthalimides. J Biomed Opt 9:1089-92 |
| Fichet, Guillaume; Comoy, Emmanuel; Duval, Christelle et al. (2004) Novel methods for disinfection of prion-contaminated medical devices. Lancet 364:521-6 |
| Juenke, JoEtta M; Brown, Paul I; Urry, Francis M et al. (2004) Specimen dilution for C2 monitoring with the Abbott TDxFLx cyclosporine monoclonal whole blood assay. Clin Chem 50:1430-3 |
| Brown, Paul D; Kline, Robert W; Petersen, Ivy A et al. (2004) Irradiation of the inguinal lymph nodes in patients of differing body habitus: a comparison of techniques and resulting normal tissue complication probabilities. Med Dosim 29:217-22 |
| Stewart, Eugene L; Brown, Peter J; Bentley, James A et al. (2004) Selection, application, and validation of a set of molecular descriptors for nuclear receptor ligands. Comb Chem High Throughput Screen 7:407-12 |
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