Abstract

Funding of all LCNSS research has been terminated, with the result that no experimental data has been generated during the past year. Nevertheless, the following 5 experiments (funded by the private sector or university medical centers) are either in progress or in preparation on off-campus sites: 1. Bioassay in mice of blood component infectivity in a mouse-adapted strain of variant CJD. 2. Bioassay in squirrel monkeys of blood component infectivity in human patients with either sporadic or variant Creutzfeldt-Jakob disease (CJD). 3. Inactivation of scrapie agent under incineration conditions of 600?C and 1000?C, assaying infectivity in both the ashed residue and vented flu gas. 4. Inactivation of scrapie agent using commercial technology of multiple ultra-high pressure pulsation. 5. Bioassay of total volume inoculations of serial dilutions of scrapie and CJD to determine if infectivity can be diluted to extinction. Note: the bibliography section is massively incomplete, as Pub Med has missed numerous articles published in many different journals, and there is no appropriate choice with which to complete the listing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002957-05
Application #
6501281
Study Section
(LCNS)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
National Institute of Neurological Disorders and Stroke
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Artwohl, James; Brown, Patricia; Corning, Brian et al. (2006) Report of the ACLAM Task Force on Rodent Euthanasia. J Am Assoc Lab Anim Sci 45:98-105
Mack, Michael J; Brown, Phillip; Houser, Frank et al. (2004) On-pump versus off-pump coronary artery bypass surgery in a matched sample of women: a comparison of outcomes. Circulation 110:II1-6
Sha, Naijun; Vannucci, Marina; Tadesse, Mahlet G et al. (2004) Bayesian variable selection in multinomial probit models to identify molecular signatures of disease stage. Biometrics 60:812-9
Sikorska, Beata; Waliyy, Anna; Bratosiewicz-Wasik, Jolanta et al. (2004) Fate of myelinated fibres in the optic nerves in experimental Creutzfeldt-Jakob disease in rodents: an ultrastructural study. Folia Neuropathol 42:101-5
Brown, Peter (2004) Action myoclonus-renal failure syndrome: the definitive clinico-pathological description. Brain 127:2151-2
Liberski, Pawel P; Brown, Paul (2004) Kuru: a half-opened window onto the landscape of neurodegenerative diseases. Folia Neuropathol 42 Suppl A:3-14
Liberski, Pawel P; Brown, Paul (2004) Prion diseases: from transmission experiments to structural biology--still searching for the cause. Folia Neuropathol 42 Suppl A:15-32
Magill, Peter J; Sharott, Andrew; Bolam, J Paul et al. (2004) Brain state-dependency of coherent oscillatory activity in the cerebral cortex and basal ganglia of the rat. J Neurophysiol 92:2122-36
Loukas, Constantinos; Brown, Peter (2004) Online prediction of self-paced hand-movements from subthalamic activity using neural networks in Parkinson's disease. J Neurosci Methods 137:193-205
Read, Jennifer P; Brown, Pamela J; Kahler, Christopher W (2004) Substance use and posttraumatic stress disorders: symptom interplay and effects on outcome. Addict Behav 29:1665-72

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