Infection And Disinfection Of Transmissible Spongiform E

Brown, Paul W.

Abstract

Funding of all LCNSS research has been terminated, with the result that no experimental data has been generated during the past year. Nevertheless, the following 5 experiments (funded by the private sector or university medical centers) are either in progress or in preparation on off-campus sites: 1. Bioassay in mice of blood component infectivity in a mouse-adapted strain of variant CJD. 2. Bioassay in squirrel monkeys of blood component infectivity in human patients with either sporadic or variant Creutzfeldt-Jakob disease (CJD). 3. Inactivation of scrapie agent under incineration conditions of 600?C and 1000?C, assaying infectivity in both the ashed residue and vented flu gas. 4. Inactivation of scrapie agent using commercial technology of multiple ultra-high pressure pulsation. 5. Bioassay of total volume inoculations of serial dilutions of scrapie and CJD to determine if infectivity can be diluted to extinction. Note: the bibliography section is massively incomplete, as Pub Med has missed numerous articles published in many different journals, and there is no appropriate choice with which to complete the listing.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Intramural Research (Z01)
• Project #: 1Z01NS002957-05
• Application #: 6501281
• Study Section: (LCNS)
• Support Year: 5
• Fiscal Year: 2001

Institution

• Name: National Institute of Neurological Disorders and Stroke
• Country: United States

Publications

Artwohl, James; Brown, Patricia; Corning, Brian et al. (2006) Report of the ACLAM Task Force on Rodent Euthanasia. J Am Assoc Lab Anim Sci 45:98-105

Liberski, Pawel P; Brown, Paul (2004) Kuru: a half-opened window onto the landscape of neurodegenerative diseases. Folia Neuropathol 42 Suppl A:3-14

Liberski, Pawel P; Brown, Paul (2004) Prion diseases: from transmission experiments to structural biology--still searching for the cause. Folia Neuropathol 42 Suppl A:15-32

Magill, Peter J; Sharott, Andrew; Bolam, J Paul et al. (2004) Brain state-dependency of coherent oscillatory activity in the cerebral cortex and basal ganglia of the rat. J Neurophysiol 92:2122-36

Loukas, Constantinos; Brown, Peter (2004) Online prediction of self-paced hand-movements from subthalamic activity using neural networks in Parkinson's disease. J Neurosci Methods 137:193-205

Read, Jennifer P; Brown, Pamela J; Kahler, Christopher W (2004) Substance use and posttraumatic stress disorders: symptom interplay and effects on outcome. Addict Behav 29:1665-72

Jarvest, Richard L; Armstrong, Sula A; Berge, John M et al. (2004) Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues. Bioorg Med Chem Lett 14:3937-41

Rowe, Kevin C; Heske, Edward J; Brown, Patrick W et al. (2004) Surviving the ice: Northern refugia and postglacial colonization. Proc Natl Acad Sci U S A 101:10355-9

McCaffrey, Ramona L; Fawcett, Paul; O'Riordan, Mary et al. (2004) A specific gene expression program triggered by Gram-positive bacteria in the cytosol. Proc Natl Acad Sci U S A 101:11386-91

Sharples, Edward J; Patel, Nimesh; Brown, Paul et al. (2004) Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol 15:2115-24