Within this program several studies are on-going MicroRNAs have been identified in serum and are thought to play a role in cancers and cardiovascular disease and may serve as a biomarker for age-related disease. We have contributed serum from monkeys over a large age range to analyze microRNA expression and compare it to that from humans. Peripheral blood mononuclear cells were collected from young and old rhesus monkeys in our colony and used to identify an evolutionary-conserved subset of B cells which increases with age in humans, monkeys and mice. We have an on-going study looking at the effectiveness of a replenished B cell population in response to a vaccination. To better understand muscle dysfunction and factors contributing to sarcopenia, we are assessing muscle and mitochondria function of young and old monkeys in comparison to young and old humans. Several samples have been collected and the analysis is on-going. A study of a PI3-Kinase inhibitor was completed to determine if oral doses of the compound altered metabolism to decrease fat mass and alter metabolism. Data analyses is on-going We have developed an exercise model and several monkeys are being trained to walk on a treadmill.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000356-02
Application #
8931521
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Gouras, Peter; Brown, Kristy R; Mattison, Julie A et al. (2018) The Ultrastructure, Spatial Distribution, and Osmium Tetroxide Binding of Lipofuscin and Melanosomes in Aging Monkey Retinal Epithelium. Curr Eye Res 43:1019-1023
Maxwell, Nicholas; Castro, Ryan W; Sutherland, Natalia M et al. (2018) ?-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice. Aging Cell 17:
Mattison, Julie A; Vaughan, Kelli L (2017) An overview of nonhuman primates in aging research. Exp Gerontol 94:41-45
Mercken, Evi M; Capri, Miriam; Carboneau, Bethany A et al. (2017) Conserved and species-specific molecular denominators in mammalian skeletal muscle aging. NPJ Aging Mech Dis 3:8
Vaughan, Kelli L; Mattison, Julie A (2016) Obesity and Aging in Humans and Nonhuman Primates: A Mini-Review. Gerontology 62:611-617
Di Biase, Stefano; Lee, Changhan; Brandhorst, Sebastian et al. (2016) Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell 30:136-146
Mera, Paula; Laue, Kathrin; Ferron, Mathieu et al. (2016) Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell Metab 23:1078-1092
Ortega-Molina, Ana; Lopez-Guadamillas, Elena; Mattison, Julie A et al. (2015) Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys. Cell Metab 21:558-70
Abdelmohsen, Kotb; Panda, Amaresh C; De, Supriyo et al. (2015) Circular RNAs in monkey muscle: age-dependent changes. Aging (Albany NY) 7:903-10
Lee-Chang, Catalina; Bodogai, Monica; Moritoh, Kanako et al. (2014) Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood 124:1450-9

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