Within this program several studies are on-going In collaboration with Dr. Biragyns lab, we depleted 4BL cells in old monkeys using daily antibiotic treatment. Fecal samples were collected throughout the study to determine if age-related changes in the microbiota are associated with changes in 4BL cells. Analysis is ongoing. We are currently testing the efficacy of an alternate anesthesia protocol that may be safer for use in older animals. Glucose and insulin response during an intravenous glucose tolerance test will be evaluated. In collaboration with the Jacobson lab, NIDDK, we have assessed adenosine receptor agonist compounds for tolerance and toxicity as a potential treatment for neuropathic pain. We are establishing memory tasks using touchscreen monitors and will be evaluating factors associated with exercise and memory. To better understand muscle dysfunction and factors contributing to sarcopenia, we are assessing muscle and mitochondria function of young and old monkeys in comparison to young and old humans. Several samples have been collected and the analysis is on-going.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000356-05
Application #
9549293
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Gouras, Peter; Brown, Kristy R; Mattison, Julie A et al. (2018) The Ultrastructure, Spatial Distribution, and Osmium Tetroxide Binding of Lipofuscin and Melanosomes in Aging Monkey Retinal Epithelium. Curr Eye Res 43:1019-1023
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Vaughan, Kelli L; Mattison, Julie A (2016) Obesity and Aging in Humans and Nonhuman Primates: A Mini-Review. Gerontology 62:611-617
Di Biase, Stefano; Lee, Changhan; Brandhorst, Sebastian et al. (2016) Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell 30:136-146
Mera, Paula; Laue, Kathrin; Ferron, Mathieu et al. (2016) Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell Metab 23:1078-1092
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Ortega-Molina, Ana; Lopez-Guadamillas, Elena; Mattison, Julie A et al. (2015) Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys. Cell Metab 21:558-70
Lee-Chang, Catalina; Bodogai, Monica; Moritoh, Kanako et al. (2014) Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood 124:1450-9

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