Abstract

The success of genetic epidemiology lies in replication of results, and more recently, joining with other cohorts to boost statistical power. To that end, this project draws on the AGES-Reykjavik Study and Health, Aging, and Body Composition (Health ABC) Study, both of which have been involved in candidate gene studies and have recently completed genome-wide association studies (GWAS). Genotypes from both studies have been imputed to 2.5 million SNPs from the international HapMap Project. The studies share several phenotypes in common - measurement of adipose tissue, muscle area, muscle density, measures of grip and quadricep strength, and assessment of physical functioning. All analysis for these bone and body composition traits will be done as a collaboration between AGES-Reykjavik and the Health ABC Studies. We will join the results in a meta-analysis and consider joining with consortia of other epidemiologic GWAS to further support or refute our findings.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG006000-02
Application #
7964160
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2009
Total Cost
$364,394
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Floyd, J S; Sitlani, C M; Avery, C L et al. (2018) Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group. Pharmacogenomics J 18:127-135
Ng, Maggie C Y; Graff, Mariaelisa; Lu, Yingchang et al. (2017) Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLoS Genet 13:e1006719
Gaksch, Martin; Jorde, Rolf; Grimnes, Guri et al. (2017) Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLoS One 12:e0170791
Graff, Mariaelisa (see original citation for additional authors) (2017) Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 13:e1006528
Li, Man; Li, Yong; Weeks, Olivia et al. (2017) SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol 28:981-994
Ben-Avraham, Dan; Karasik, David; Verghese, Joe et al. (2017) The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY) 9:209-246
Jensen, Majken K; Jensen, Richard A; Mukamal, Kenneth J et al. (2017) Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Hum Mol Genet 26:2156-2163
Justice, Anne E (see original citation for additional authors) (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun 8:14977
van Rooij, Frank J A; Qayyum, Rehan; Smith, Albert V et al. (2017) Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet 100:51-63
Noordam, Raymond; Sitlani, Colleen M; Avery, Christy L et al. (2017) A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet 54:313-323

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