Abstract

We initated this research project this year in collaboration with Sanaria Inc and the Malaria Research and Training Center at the University of Bamako, Mali. The protocol has been designed and is currently under scientific review. The information sheet and consent forms have been developed, and the case report forms are currently being drafted. Laboratory assays required for this study (i.e. P. flaciparum PCR) are currently established in our laboratory. Initial orders of items required for this study have been placed. It is planned to begin screening in Mali in November 2012, subject to availability of the relevant approvals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001170-01
Application #
8556073
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2012
Total Cost
$82,791
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Zaidi, Irfan; Duffy, Patrick E (2018) Response to Comment on ""?? T Cells Are Required for the Induction of Sterile Immunity during Irradiated Sporozoite Vaccinations"". J Immunol 200:1533-1534
Pichugin, Alexander; Zarling, Stasya; Perazzo, Leah et al. (2018) Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen. Front Immunol 9:91
Conteh, Solomon; Anderson, Charles; Lambert, Lynn et al. (2017) Grammomys surdaster, the Natural Host for Plasmodium berghei Parasites, as a Model to Study Whole-Organism Vaccines Against Malaria. Am J Trop Med Hyg 96:835-841
Hobbs, Charlotte V; Anderson, Charles; Neal, Jillian et al. (2017) Trimethoprim-Sulfamethoxazole Prophylaxis During Live Malaria Sporozoite Immunization Induces Long-Lived, Homologous, and Heterologous Protective Immunity Against Sporozoite Challenge. J Infect Dis 215:122-130
Sissoko, Mahamadou S; Healy, Sara A; Katile, Abdoulaye et al. (2017) Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial. Lancet Infect Dis 17:498-509
Sahu, Tejram; Lambert, Lynn; Herrod, Jessica et al. (2015) Chloroquine neither eliminates liver stage parasites nor delays their development in a murine Chemoprophylaxis Vaccination model. Front Microbiol 6:283
Hoffman, Stephen L; Vekemans, Johan; Richie, Thomas L et al. (2015) The march toward malaria vaccines. Vaccine 33 Suppl 4:D13-23
Richie, Thomas L; Billingsley, Peter F; Sim, B Kim Lee et al. (2015) Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines. Vaccine 33:7452-61
Hoffman, Stephen L; Vekemans, Johan; Richie, Thomas L et al. (2015) The March Toward Malaria Vaccines. Am J Prev Med 49:S319-33