Abstract

This research project was initiated in 2012 in collaboration with Sanaria Inc and the Malaria Research and Training Center at the University of Bamako, Mali. In 2012, we developed the clinical trials protocol for the CVac study, obtained all required approvals, and prepared the study site by December 2012. Due to the civil unrest in Mali the trial could not be started in April 2013 as planned. Since January 2013, we have designed the second study to test the safety, immunogenicity and efficacy against naturally occurring malaria transmission of PfSPZ Vaccine in Malian adults. This protocol has undergone scientific review in July 2013. Together with our collaborators we have decided to give the study testing PfSPZ Vaccine priority. The planned study start is in December 2013.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001170-02
Application #
8745584
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2013
Total Cost
$165,585
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Zaidi, Irfan; Duffy, Patrick E (2018) Response to Comment on ""?? T Cells Are Required for the Induction of Sterile Immunity during Irradiated Sporozoite Vaccinations"". J Immunol 200:1533-1534
Pichugin, Alexander; Zarling, Stasya; Perazzo, Leah et al. (2018) Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen. Front Immunol 9:91
Hobbs, Charlotte V; Anderson, Charles; Neal, Jillian et al. (2017) Trimethoprim-Sulfamethoxazole Prophylaxis During Live Malaria Sporozoite Immunization Induces Long-Lived, Homologous, and Heterologous Protective Immunity Against Sporozoite Challenge. J Infect Dis 215:122-130
Sissoko, Mahamadou S; Healy, Sara A; Katile, Abdoulaye et al. (2017) Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial. Lancet Infect Dis 17:498-509
Conteh, Solomon; Anderson, Charles; Lambert, Lynn et al. (2017) Grammomys surdaster, the Natural Host for Plasmodium berghei Parasites, as a Model to Study Whole-Organism Vaccines Against Malaria. Am J Trop Med Hyg 96:835-841
Sahu, Tejram; Lambert, Lynn; Herrod, Jessica et al. (2015) Chloroquine neither eliminates liver stage parasites nor delays their development in a murine Chemoprophylaxis Vaccination model. Front Microbiol 6:283
Hoffman, Stephen L; Vekemans, Johan; Richie, Thomas L et al. (2015) The march toward malaria vaccines. Vaccine 33 Suppl 4:D13-23
Richie, Thomas L; Billingsley, Peter F; Sim, B Kim Lee et al. (2015) Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines. Vaccine 33:7452-61
Hoffman, Stephen L; Vekemans, Johan; Richie, Thomas L et al. (2015) The March Toward Malaria Vaccines. Am J Prev Med 49:S319-33