Abstract

Using population-based approaches and biomarker assays on stored samples (in exisiting large biobanks) allows my research to move forward more quickly. I can use these strategies in parallel with my clinical program - to test important questions and to identify candidate assays and targets. In parallel, I develop prospective patient studies for individuals affected with myeloma precursor disease, early intervention studies (MGUS and smoldering myeloma), and targeted myeloma treatment studies. By taking these parallel approaches, and by constantly developing and improving our concepts, I bevieve that we will be able to delay progression and ultimately cure patients from myeloma in the future. Currently, we are developing a myeloma mouse model.
The aim of this effort is to develop a model to study mechanisms of disease, and to allow us to do drug screening.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011205-02
Application #
8157697
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2010
Total Cost
$97,324
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Manasanch, Elisabet E; Kristinsson, Sigurdur Y; Landgren, Ola (2013) Etiology of Waldenstrom macroglobulinemia: genetic factors and immune-related conditions. Clin Lymphoma Myeloma Leuk 13:194-7
Kristinsson, Sigurdur Y; Eloranta, Sandra; Dickman, Paul W et al. (2013) Patterns of survival in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia: a population-based study of 1,555 patients diagnosed in Sweden from 1980 to 2005. Am J Hematol 88:60-5
Drahos, Jennifer; Vanwormer, Jeffrey J; Greenlee, Robert T et al. (2013) Accuracy of ICD-9-CM codes in identifying infections of pneumonia and herpes simplex virus in administrative data. Ann Epidemiol 23:291-3
Wu, S Peter; Minter, Alex; Costello, Rene et al. (2013) MGUS prevalence in an ethnically Chinese population in Hong Kong. Blood 121:2363-4
Shiels, Meredith S; Landgren, Ola; Goedert, James J et al. (2013) Reply to bibas et Al. Clin Infect Dis 56:1350
Engels, Eric A; Savoldo, Barbara; Pfeiffer, Ruth M et al. (2013) Plasma markers of B-cell activation and clonality in pediatric liver and hematopoietic stem cell transplant recipients. Transplantation 95:519-26
Katzmann, J A; Clark, R; Kyle, R A et al. (2013) Suppression of uninvolved immunoglobulins defined by heavy/light chain pair suppression is a risk factor for progression of MGUS. Leukemia 27:208-12
Kristinsson, Sigurdur Y; Pfeiffer, Ruth M; Bjorkholm, Magnus et al. (2012) Thrombosis is associated with inferior survival in multiple myeloma. Haematologica 97:1603-7
Kristinsson, S Y; Goldin, L; Turesson, I et al. (2012) Family history of venous thromboembolism is associated with increased risk for thrombosis in multiple myeloma: a population-based study. J Thromb Haemost 10:962-4
Hultcrantz, Malin; Kristinsson, Sigurdur Yngvi; Andersson, Therese M-L et al. (2012) Patterns of survival among patients with myeloproliferative neoplasms diagnosed in Sweden from 1973 to 2008: a population-based study. J Clin Oncol 30:2995-3001

Showing the most recent 10 out of 52 publications