Abstract

Using population-based approaches and biomarker assays on stored samples (in exisiting large biobanks) allows my research to move forward more quickly. I can use these strategies in parallel with my clinical program - to test important questions and to identify candidate assays and targets. In parallel, I develop prospective patient studies for individuals affected with myeloma precursor disease, early intervention studies (MGUS and smoldering myeloma), and targeted myeloma treatment studies. By taking these parallel approaches, and by constantly developing and improving our concepts, I bevieve that we will be able to delay progression and ultimately cure patients from myeloma in the future. Currently, we are developing in vitro models.
The aim of this effort is to develop models to study mechanisms of disease, and to allow us to do drug screening.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011205-06
Application #
8938008
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Manasanch, Elisabet E; Kristinsson, Sigurdur Y; Landgren, Ola (2013) Etiology of Waldenstrom macroglobulinemia: genetic factors and immune-related conditions. Clin Lymphoma Myeloma Leuk 13:194-7
Kristinsson, Sigurdur Y; Eloranta, Sandra; Dickman, Paul W et al. (2013) Patterns of survival in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia: a population-based study of 1,555 patients diagnosed in Sweden from 1980 to 2005. Am J Hematol 88:60-5
Drahos, Jennifer; Vanwormer, Jeffrey J; Greenlee, Robert T et al. (2013) Accuracy of ICD-9-CM codes in identifying infections of pneumonia and herpes simplex virus in administrative data. Ann Epidemiol 23:291-3
Wu, S Peter; Minter, Alex; Costello, Rene et al. (2013) MGUS prevalence in an ethnically Chinese population in Hong Kong. Blood 121:2363-4
Shiels, Meredith S; Landgren, Ola; Goedert, James J et al. (2013) Reply to bibas et Al. Clin Infect Dis 56:1350
Engels, Eric A; Savoldo, Barbara; Pfeiffer, Ruth M et al. (2013) Plasma markers of B-cell activation and clonality in pediatric liver and hematopoietic stem cell transplant recipients. Transplantation 95:519-26
Katzmann, J A; Clark, R; Kyle, R A et al. (2013) Suppression of uninvolved immunoglobulins defined by heavy/light chain pair suppression is a risk factor for progression of MGUS. Leukemia 27:208-12
Auner, Holger W; Pavlu, Jiri; Szydlo, Richard et al. (2012) Autologous haematopoietic stem cell transplantation in multiple myeloma patients from ethnic minority groups in an equal access healthcare system. Br J Haematol 157:125-7
Sjoberg, Jan; Halthur, Cat; Kristinsson, Sigurdur Y et al. (2012) Progress in Hodgkin lymphoma: a population-based study on patients diagnosed in Sweden from 1973-2009. Blood 119:990-6
Birmann, Brenda M; Neuhouser, Marian L; Rosner, Bernard et al. (2012) Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium. Blood 120:4929-37

Showing the most recent 10 out of 52 publications