Abstract

This project has been inititated within the last month, and at present, there are no definitive conclusions to report. We are currently gathering data to determine the histologic and molecular differences in breast cancer brain metastases as a function of differing fractionation regimens for WBRT in a mouse model. We also hope to determine histologic and molecular differences in breast cancer brain metastases as a function of differing single hemibrain radiation doses using immunohistochemical and proteomic methods. Ultimately, we hope to correlate the finding to a quantitative measure of neurocognitive deficit produced from differing radiation dosing and fractionation schedules for treatment of breast cancer brain metastases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011330-01
Application #
8157773
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2010
Total Cost
$144,782
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Smart, DeeDee; Garcia-Glaessner, Alejandra; Palmieri, Diane et al. (2015) Analysis of radiation therapy in a model of triple-negative breast cancer brain metastasis. Clin Exp Metastasis 32:717-27
Gril, Brunilde; Palmieri, Diane; Qian, Yong et al. (2011) Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis. Clin Cancer Res 17:142-53