Over the past several years, our group has been focused on studying genes with neuromodulatory, neuroprotective and/or neuroregenerative effects in models of neurodegeneration and neurotoxicity. We primarily have examined how the MANF/CDNF protein family can improve neuronal survival during injury or disease states. We published paper showing MANF has protective effects when administered after stroke. In collaboration with Dr. Airavaara (U Helsinki), we examined the neuroprotective actions of two isoforms of the dopaminergic neurotrophic factor, GDNF. This work is now published in Frontiers of Neurology. In collaboration with Yun Wang (NHRI, Taiwan) we demonstrate how 9-cis retinoic acid promotes neurorepair through the action of trophic factors and improves the recovery from an ischemic injury in a rat model of stroke.
| Mätlik, Kert; Anttila, Jenni E; Kuan-Yin, Tseng et al. (2018) Poststroke delivery of MANF promotes functional recovery in rats. Sci Adv 4:eaap8957 |
| Anttila, Jenni E; Albert, Katrina; Wires, Emily S et al. (2018) Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury. eNeuro 5: |
| Yu, Seong-Jin; Airavaara, Mikko; Wu, Kuo-Jen et al. (2017) 9-cis retinoic acid induces neurorepair in stroke brain. Sci Rep 7:4512 |
| Baldwin, Heather A; Koivula, Pyry P; Necarsulmer, Julie C et al. (2017) Step Sequence Is a Critical Gait Parameter of Unilateral 6-OHDA Parkinson's Rat Models. Cell Transplant 26:659-667 |
| Song, Kang-Ho; Fan, Alexander C; Hinkle, Joshua J et al. (2017) Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound. Theranostics 7:144-152 |
| Wallace, Veronica J; Cimbro, Raffaello; Rubio, F Javier et al. (2017) Neurons Internalize Functionalized Micron-Sized Silicon Dioxide Microspheres. Cell Mol Neurobiol 37:1487-1499 |
| Koskela, Maryna; Bäck, Susanne; Võikar, Vootele et al. (2017) Update of neurotrophic factors in neurobiology of addiction and future directions. Neurobiol Dis 97:189-200 |
| Howard, Douglas B; Harvey, Brandon K (2017) Assaying the Stability and Inactivation of AAV Serotype 1 Vectors. Hum Gene Ther Methods 28:39-48 |
| Anttila, Jenni E; Whitaker, Keith W; Wires, Emily S et al. (2017) Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Prog Neuropsychopharmacol Biol Psychiatry 79:3-14 |
| Wires, Emily S; Henderson, Mark J; Yan, Xiaokang et al. (2017) Longitudinal monitoring of Gaussia and Nano luciferase activities to concurrently assess ER calcium homeostasis and ER stress in vivo. PLoS One 12:e0175481 |
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