In this year, we completed two major sub-projects. First, we employed glutamate-sensitive sensors coupled with high-speed amperometry to evaluate rapid changes in glutamate following exposure to natural arousing stimuli, cocaine and nicotine. Second, we employed glucose-sensitive sensors coupled with high-speed amperometry to evaluate rapid fluctuations in brain glucose levels following exposure to natural stimuli and drugs of abuse (cocaine and nicotine). We also initiated third project, in which we want to examine how glucose enters the brain after iv injections of several drugs of abuse with different mechanisms of action (cocaine, methamphetamine and MDPV). This work will be expanded during the next years to include more complicated behavioral paradigms that involve the use of addictive drugs.

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2013
Total Cost
$623,509
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code
Solis Jr, Ernesto; Afzal, Anum; Kiyatkin, Eugene A (2018) Changes in brain oxygen and glucose induced by oxycodone: Relationships with brain temperature and peripheral vascular tone. Neuropharmacology 133:481-490
Solis Jr, Ernesto; Bola, R Aaron; Fasulo, Bradley J et al. (2017) Brain Hyperglycemia Induced by Heroin: Association with Metabolic Neural Activation. ACS Chem Neurosci 8:265-271
Solis Jr, Ernesto; Cameron-Burr, Keaton T; Kiyatkin, Eugene A (2017) Heroin Contaminated with Fentanyl Dramatically Enhances Brain Hypoxia and Induces Brain Hypothermia. eNeuro 4:
Solis Jr, Ernesto; Cameron-Burr, Keaton T; Shaham, Yavin et al. (2017) Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response. eNeuro 4:
Bola, R Aaron; Kiyatkin, Eugene A (2017) Brain temperature effects of intravenous heroin: State dependency, environmental modulation, and the effects of dose. Neuropharmacology 126:271-280
Solis, Ernesto; Cameron-Burr, Keaton T; Shaham, Yavin et al. (2017) Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature. Neuropsychopharmacology :
Solis Jr, Ernesto; Cameron-Burr, Keaton T; Kiyatkin, Eugene A (2017) Rapid Physiological Fluctuations in Nucleus Accumbens Oxygen Levels Induced by Arousing Stimuli: Relationships with Changes in Brain Glucose and Metabolic Neural Activation. Front Integr Neurosci 11:9
Bola, R Aaron; Kiyatkin, Eugene A (2016) Robust Brain Hyperglycemia during General Anesthesia: Relationships with Metabolic Brain Inhibition and Vasodilation. Front Physiol 7:39
Wakabayashi, Ken T; Spekterman, Laurence; Kiyatkin, Eugene A (2016) Experience-dependent escalation of glucose drinking and the development of glucose preference over fructose - association with glucose entry into the brain. Eur J Neurosci 43:1422-30
Wakabayashi, Ken T; Kiyatkin, Eugene A (2015) Central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine. Front Neurosci 9:42

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